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Mouse Anti-MTPN (AA 1-118) Recombinant Antibody (CBFYM-2768) (CBMAB-M2961-FY)

This product is mouse antibody that recognizes MTPN. The antibody CBFYM-2768 can be used for immunoassay techniques such as: ELISA, IF, WB.
See all MTPN antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYM-2768
Antibody Isotype
IgG2a, k
Application
ELISA, IF, WB

Basic Information

Immunogen
Full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.Immunogen sequence: MCDKEFMWAL KNGGLDEVKD YVAKGEDVNR TLEGGRKPLH YAADCGQLEI LEFLLLKGAD INAPDKHHIT PLLSAVYEGH VSCVKLLLSK GADKTVKGPD GLTAFEATDN QAIKALLQ
Specificity
Human
Antibody Isotype
IgG2a, k
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 1-118

Target

Full Name
myotrophin
Introduction
The transcript produced from this gene is bi-cistronic and can encode both myotrophin and leucine zipper protein 6. The myotrophin protein is associated with cardiac hypertrophy, where it is involved in the conversion of NFkappa B p50-p65 heterodimers to p50-p50 and p65-p65 homodimers. This protein also has a potential function in cerebellar morphogenesis, and it may be involved in the differentiation of cerebellar neurons, particularly of granule cells. A cryptic ORF at the 3' end of this transcript uses a novel internal ribosome entry site and a non-AUG translation initiation codon to produce leucine zipper protein 6, a 6.4 kDa tumor antigen that is associated with myeloproliferative disease.
Entrez Gene ID
136319
UniProt ID
P58546
Alternative Names
Myotrophin; Granule Cell Differentiation Protein; Protein V-1; GCDP; V-1
Function
Promotes dimerization of NF-kappa-B subunits and regulates NF-kappa-B transcription factor activity (By similarity).

Plays a role in the regulation of the growth of actin filaments. Inhibits the activity of the F-actin-capping protein complex formed by the CAPZA1 and CAPZB heterodimer. Promotes growth of cardiomyocytes, but not cardiomyocyte proliferation. Promotes cardiac muscle hypertrophy.
Biological Process
Catecholamine metabolic process Source: Ensembl
Cellular response to mechanical stimulus Source: Ensembl
Cerebellar granule cell differentiation Source: Ensembl
Neuron differentiation Source: UniProtKB
Positive regulation of cardiac muscle hypertrophy Source: UniProtKB
Positive regulation of cell growth Source: UniProtKB
Positive regulation of macromolecule biosynthetic process Source: UniProtKB
Positive regulation of NF-kappaB transcription factor activity Source: UniProtKB
Positive regulation of protein metabolic process Source: UniProtKB
Regulation of barbed-end actin filament capping Source: UniProtKB
Regulation of cell size Source: UniProtKB
Regulation of striated muscle tissue development Source: UniProtKB
Regulation of translation Source: UniProtKB
Skeletal muscle tissue regeneration Source: Ensembl
Striated muscle cell differentiation Source: Ensembl
Cellular Location
Cytoplasm
Nucleus
Other locations
perinuclear region
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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