Mouse Anti-MTPN (AA 1-118) Recombinant Antibody (CBFYM-2768) (CBMAB-M2961-FY)

Name: Mouse Anti-MTPN (AA 1-118) Recombinant Antibody (CBFYM-2768)
SKU: CBMAB-M2961-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBFYM-2768

Application

ELISA, IF, WB

Immunogen

Full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.Immunogen sequence: MCDKEFMWAL KNGGLDEVKD YVAKGEDVNR TLEGGRKPLH YAADCGQLEI LEFLLLKGAD INAPDKHHIT PLLSAVYEGH VSCVKLLLSK GADKTVKGPD GLTAFEATDN QAIKALLQ

Specificity

Human

Antibody Isotype

IgG2a, k

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

AA 1-118

More Infomation

Target

Full Name

myotrophin

Introduction

The transcript produced from this gene is bi-cistronic and can encode both myotrophin and leucine zipper protein 6. The myotrophin protein is associated with cardiac hypertrophy, where it is involved in the conversion of NFkappa B p50-p65 heterodimers to p50-p50 and p65-p65 homodimers. This protein also has a potential function in cerebellar morphogenesis, and it may be involved in the differentiation of cerebellar neurons, particularly of granule cells. A cryptic ORF at the 3' end of this transcript uses a novel internal ribosome entry site and a non-AUG translation initiation codon to produce leucine zipper protein 6, a 6.4 kDa tumor antigen that is associated with myeloproliferative disease.

Entrez Gene ID

136319

UniProt ID

P58546

Alternative Names

Myotrophin; Granule Cell Differentiation Protein; Protein V-1; GCDP; V-1

Function

Promotes dimerization of NF-kappa-B subunits and regulates NF-kappa-B transcription factor activity (By similarity).

Plays a role in the regulation of the growth of actin filaments. Inhibits the activity of the F-actin-capping protein complex formed by the CAPZA1 and CAPZB heterodimer. Promotes growth of cardiomyocytes, but not cardiomyocyte proliferation. Promotes cardiac muscle hypertrophy.

Biological Process

Catecholamine metabolic process Source: Ensembl
Cellular response to mechanical stimulus Source: Ensembl
Cerebellar granule cell differentiation Source: Ensembl
Neuron differentiation Source: UniProtKB
Positive regulation of cardiac muscle hypertrophy Source: UniProtKB
Positive regulation of cell growth Source: UniProtKB
Positive regulation of macromolecule biosynthetic process Source: UniProtKB
Positive regulation of NF-kappaB transcription factor activity Source: UniProtKB
Positive regulation of protein metabolic process Source: UniProtKB
Regulation of barbed-end actin filament capping Source: UniProtKB
Regulation of cell size Source: UniProtKB
Regulation of striated muscle tissue development Source: UniProtKB
Regulation of translation Source: UniProtKB
Skeletal muscle tissue regeneration Source: Ensembl
Striated muscle cell differentiation Source: Ensembl

Cellular Location

Cytoplasm
Nucleus
Other locations
perinuclear region

Wang, Y., Zhang, W., Chen, L., Chen, W., Xu, S., Tang, L., ... & Miao, L. (2021). The ATO/miRNA-885-5p/MTPN axis induces reversal of drug-resistance in cholangiocarcinoma. Cellular Oncology, 44(4), 907-916.

Wang, C., Sha, Y., Wang, S., Chi, Q., Sung, K. P., Xu, K., & Yang, L. (2020). Lysyl oxidase suppresses the inflammatory response in anterior cruciate ligament fibroblasts and promotes tissue regeneration by targeting myotrophin via the nuclear factor‐kappa B pathway. Journal of Tissue Engineering and Regenerative Medicine, 14(8), 1063-1076.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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