MTPN

The transcript produced from this gene is bi-cistronic and can encode both myotrophin and leucine zipper protein 6. The myotrophin protein is associated with cardiac hypertrophy, where it is involved in the conversion of NFkappa B p50-p65 heterodimers to p50-p50 and p65-p65 homodimers. This protein also has a potential function in cerebellar morphogenesis, and it may be involved in the differentiation of cerebellar neurons, particularly of granule cells. A cryptic ORF at the 3' end of this transcript uses a novel internal ribosome entry site and a non-AUG translation initiation codon to produce leucine zipper protein 6, a 6.4 kDa tumor antigen that is associated with myeloproliferative disease. [provided by RefSeq]

myotrophin

Promotes dimerization of NF-kappa-B subunits and regulates NF-kappa-B transcription factor activity (By similarity).

Plays a role in the regulation of the growth of actin filaments. Inhibits the activity of the F-actin-capping protein complex formed by the CAPZA1 and CAPZB heterodimer. Promotes growth of cardiomyocytes, but not cardiomyocyte proliferation. Promotes cardiac muscle hypertrophy.

Catecholamine metabolic process Source: Ensembl
Cellular response to mechanical stimulus Source: Ensembl
Cerebellar granule cell differentiation Source: Ensembl
Neuron differentiation Source: UniProtKB
Positive regulation of cardiac muscle hypertrophy Source: UniProtKB
Positive regulation of cell growth Source: UniProtKB
Positive regulation of macromolecule biosynthetic process Source: UniProtKB
Positive regulation of NF-kappaB transcription factor activity Source: UniProtKB
Positive regulation of protein metabolic process Source: UniProtKB
Regulation of barbed-end actin filament capping Source: UniProtKB
Regulation of cell size Source: UniProtKB
Regulation of striated muscle tissue development Source: UniProtKB
Regulation of translation Source: UniProtKB
Skeletal muscle tissue regeneration Source: Ensembl
Striated muscle cell differentiation Source: Ensembl

Cytoplasm
Nucleus
Other locations
perinuclear region