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Mouse Anti-NEUROG1 Recombinant Antibody (10B10) (CBMAB-N2060-WJ)

This product is a Mouse antibody that recognizes NEUROG1. The antibody 10B10 can be used for immunoassay techniques such as: IP, WB.
See all NEUROG1 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Monkey
Clone
10B10
Antibody Isotype
IgG1
Application
IP, WB

Basic Information

Specificity
Human, Monkey
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.3, 1% BSA, 50% glycerol
Preservative
0.02% sodium azide
Concentration
0.55 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
neurogenin 1
Introduction
Acts as a transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5-CANNTG-3). Associates with chromatin to enhancer regulatory elements in genes encoding key transcriptional regulators of neurogenesis (By similarity).
Entrez Gene ID
Human4762
Monkey711992
UniProt ID
HumanQ92886
MonkeyF6SM19
Alternative Names
Neurogenin 1; Neurogenic Basic-Helix-Loop-Helix Protein; Class A Basic Helix-Loop-Helix Protein 6; Neurogenic Differentiation Factor 3; Neurogenic Differentiation 3; NEUROD3; BHLHa6;
Function
Acts as a transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). Associates with chromatin to enhancer regulatory elements in genes encoding key transcriptional regulators of neurogenesis (By similarity).
Biological Process
Auditory behavior Source: CAFA
Cell fate commitment Source: Ensembl
Cochlea development Source: CAFA
Cochlea morphogenesis Source: CAFA
Craniofacial suture morphogenesis Source: CAFA
Genitalia development Source: CAFA
Genitalia morphogenesis Source: CAFA
Hard palate morphogenesis Source: CAFA
Inner ear development Source: CAFA
Inner ear morphogenesis Source: CAFA
Learned vocalization behavior Source: CAFA
Mastication Source: CAFA
Negative regulation of relaxation of muscle Source: CAFA
Negative regulation of saliva secretion Source: CAFA
Nervous system development Source: ProtInc
Neuromuscular process controlling balance Source: CAFA
Neuron differentiation Source: GO_Central
Peristalsis Source: CAFA
Positive regulation of DNA-binding transcription factor activity Source: UniProtKB
Positive regulation of exit from mitosis Source: Ensembl
Positive regulation of neuron differentiation Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: UniProtKB
Regulation of muscle organ development Source: CAFA
Regulation of transcription by RNA polymerase II Source: GO_Central
Thorax and anterior abdomen determination Source: CAFA
Trigeminal nerve development Source: CAFA
Vestibulocochlear nerve formation Source: CAFA
Cellular Location
Nucleus

Altbürger, C., Rath, M., Armbruster, D., & Driever, W. (2024). Neurog1 and Olig2 integrate patterning and neurogenesis signals in development of zebrafish dopaminergic and glutamatergic dual transmitter neurons. Developmental Biology, 505, 85-98.

Sheth, F., Shah, J., Patel, K., Patel, D., Jain, D., Sheth, J., & Sheth, H. (2023). A novel case of two siblings harbouring homozygous variant in the NEUROG1 gene with autism as an additional phenotype: a case report. BMC neurology, 23(1), 20.

Song, E. C., Park, C., Shin, Y., Kim, W. K., Kim, S. B., & Cho, S. (2023). Neurog1-Derived Peptides RMNE1 and DualPep-Shine Penetrate the Skin and Inhibit Melanin Synthesis by Regulating MITF Transcription. International Journal of Molecular Sciences, 24(7), 6158.

Elliott, K. L., Pavlinkova, G., Chizhikov, V. V., Yamoah, E. N., & Fritzsch, B. (2021). Neurog1, Neurod1, and Atoh1 are essential for spiral ganglia, cochlear nuclei, and cochlear hair cell development. Faculty Reviews, 10.

Dupont, J., Vieira, J. P., Tavares, A. L. T., Conceição, C. R., Khan, S., Bertoli‐Avella, A. M., & Sousa, A. B. (2021). Adding evidence to the role of NEUROG1 in congenital cranial dysinnervation disorders. Clinical Genetics, 99(4), 588-593.

Otero-Estévez, O., Gallardo-Gomez, M., Páez de la Cadena, M., Rodríguez-Berrocal, F. J., Cubiella, J., Hernandez Ramirez, V., ... & De Chiara, L. (2020). Value of serum NEUROG1 Methylation for the detection of advanced adenomas and colorectal cancer. Diagnostics, 10(7), 437.

Lu, C., Shi, X., Allen, A., Baez-Nieto, D., Nikish, A., Sanjana, N. E., & Pan, J. Q. (2019). Overexpression of NEUROG2 and NEUROG1 in human embryonic stem cells produces a network of excitatory and inhibitory neurons. The FASEB Journal, 33(4), 5287.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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