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Mouse Anti-NMBR Recombinant Antibody (CBWJN-1002) (CBMAB-N0421-WJ)

This product is a Mouse antibody that recognizes NMBR. The antibody CBWJN-1002 can be used for immunoassay techniques such as: FC.
See all NMBR antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBWJN-1002
Antibody Isotype
IgG2a
Application
FC

Basic Information

Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
PBS, Trehalose
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Neuromedin B Receptor
Introduction
This gene encodes a 7-transmembrane G protein-coupled receptor that binds neuromedin B, which is a growth factor and mitogen for gastrointestinal epithelial tissue and for normal and neoplastic lung. This receptor may play a role in smooth muscle contraction, neuronal responses, and the regulation of cell growth. Antagonists of this receptor have a potential therapeutic use in inhibiting tumor cell growth. Polymorphisms in this gene may be associated with a susceptibility for schizophrenia. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2016]
Entrez Gene ID
4829
UniProt ID
P28336
Alternative Names
Neuromedin B Receptor; Neuromedin-B-Preferring Bombesin Receptor; Epididymis Tissue Protein Li 185a; Bombesin Receptor 1; NMB-R; Epididymis Secretory Sperm Binding Protein Li 185a; Neuromedin-B Receptor; BB1R; BB1;
Function
Receptor for neuromedin-B (PubMed:1655761).
Contributes to the maintenance of basal sigh rate through signaling in the pre-Botzinger complex, a cluster of several thousand neurons in the ventrolateral medulla responsible for inspiration during respiratory activity (By similarity).
Contributes to the induction of sneezing following exposure to chemical irritants or allergens which causes release of NMB by nasal sensory neurons and activation of NMBR-expressing neurons in the sneeze-evoking region of the brainstem (By similarity).
These in turn activate neurons of the caudal ventral respiratory group, giving rise to the sneezing response (By similarity).
Contributes to induction of acute itch, possibly through its activation on dorsal root ganglion neurons by the NMB peptide (By similarity).
Plays a role in the innate immune response to influenza A virus infection by enhancing interferon alpha expression and reducing expression of IL6 (PubMed:31601264).
Plays a role in CSF1-induced proliferation of osteoclast precursors by contributing to the positive regulation of the expression of the CSF1 receptor CSF1R (By similarity).
Biological Process
G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Phospholipase C-activating G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Cell membrane
Topology
Extracellular: 1-41
Helical: 42-65
Cytoplasmic: 66-79
Helical: 80-99
Extracellular: 100-117
Helical: 118-139
Cytoplasmic: 140-156
Helical: 157-177
Extracellular: 178-211
Helical: 212-235
Cytoplasmic: 236-266
Helical: 267-287
Extracellular: 288-299
Helical: 300-327
Cytoplasmic: 328-390

Sekizaki, T., Kameda, H., Nakamura, A., Kuwabara, S., Nomoto, H., Cho, K. Y., ... & Atsumi, T. (2023). Neuromedin B receptor as a potential therapeutic target for corticotroph adenomas. Pituitary, 26(5), 597-610.

Bento-Bernardes, T., Rossetti, C. L., Borba Vieira de Andrade, C., Lopes de Souza, L., Wilieman Cabral, M., Silva Monteiro de Paula, G., ... & Cabanelas Pazos-Moura, C. (2022). Disruption of neuromedin B receptor improves mitochondrial oxidative phosphorylation capacity in gastrocnemius muscle of female mice. American Journal of Physiology-Endocrinology and Metabolism, 322(3), E250-E259.

Zhang, Y., Qian, Z., Jiang, D., Sun, Y., Gao, S., Jiang, X., ... & Tao, J. (2021). Neuromedin B receptor stimulation of Cav3. 2 T-type Ca2+ channels in primary sensory neurons mediates peripheral pain hypersensitivity. Theranostics, 11(19), 9342.

Tang, M. Y., Ma, Y. J., Tian, S. M., Wan, Q. H., & Yang, G. H. (2021). The signaling pathway of neuromedin B and its receptor NMBR involvement in anti-influenza A virus H1N1 subtype infection.

Chen, J., Shi, Y., Huang, J., Luo, J., & Zhang, W. (2020). Neuromedin B receptor mediates neuromedin B-induced COX-2 and IL-6 expression in human primary myometrial cells. Journal of Investigative Medicine, 68(6), 1171-1178.

Rametta, R., Dongiovanni, P., Baselli, G. A., Pelusi, S., Meroni, M., Fracanzani, A. L., ... & Valenti, L. (2020). Impact of natural neuromedin‐B receptor variants on iron metabolism. American Journal of Hematology, 95(2), 167-177.

Yang, G., Huang, H., Tang, M., Cai, Z., Huang, C., Qi, B., & Chen, J. L. (2019). Role of neuromedin B and its receptor in the innate immune responses against influenza A virus infection in vitro and in vivo. Veterinary research, 50(1), 80.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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