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Mouse Anti-NPY Recombinant Antibody (NA) (CBMAB-AO809LY)

The product is antibody recognizes NPY. The antibody NA immunoassay techniques such as: ELISA, IHC.
See all NPY antibodies

Summary

Host Animal
Mouse
Specificity
Human, Rat, Mouse
Clone
NA
Antibody Isotype
IgG1
Application
ELISA, IHC

Basic Information

Immunogen
Synthetic human/rat NPY adsorbed onto aluminum hydroxide gel
Specificity
Human, Rat, Mouse
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Preservative
0.09% sodium azide
Concentration
1 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Neuropeptide Y
Introduction
This gene encodes a neuropeptide that is widely expressed in the central nervous system and influences many physiological processes, including cortical excitability, stress response, food intake, circadian rhythms, and cardiovascular function. The neuropeptide functions through G protein-coupled receptors to inhibit adenylyl cyclase, activate mitogen-activated protein kinase (MAPK), regulate intracellular calcium levels, and activate potassium channels. A polymorphism in this gene resulting in a change of leucine 7 to proline in the signal peptide is associated with elevated cholesterol levels, higher alcohol consumption, and may be a risk factor for various metabolic and cardiovascular diseases. The protein also exhibits antimicrobial activity against bacteria and fungi. [provided by RefSeq, Oct 2014]
Entrez Gene ID
Human4852
Mouse109648
Rat24604
UniProt ID
HumanP01303
MouseP57774
RatP07808
Alternative Names
Neuropeptide Y; npy
Function
NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone.
Biological Process
Adult feeding behaviorISS:HGNC-UCL
AgingIEA:Ensembl
Antibacterial humoral responseIDA:UniProtKB
Antifungal humoral responseIDA:UniProtKB
Antimicrobial humoral immune response mediated by antimicrobial peptideIDA:UniProtKB
Central nervous system neuron developmentManual Assertion Based On ExperimentIEP:DFLAT
Cerebral cortex developmentManual Assertion Based On ExperimentIEP:DFLAT
Chemical synaptic transmissionManual Assertion Based On ExperimentTAS:ProtInc
Defense response to Gram-negative bacteriumIDA:UniProtKB
Defense response to Gram-positive bacteriumIDA:UniProtKB
Feeding behaviorManual Assertion Based On ExperimentIBA:GO_Central
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerManual Assertion Based On ExperimentTAS:ProtInc
Innate immune responseIDA:UniProtKB
Intestinal epithelial cell differentiationManual Assertion Based On ExperimentTAS:GO_Central
Monocyte activationIEA:Ensembl
Negative regulation of acute inflammatory response to antigenic stimulusIEA:Ensembl
Negative regulation of blood pressureIEA:Ensembl
Negative regulation of neuron deathIEA:Ensembl
Neuron projection developmentManual Assertion Based On ExperimentIEP:DFLAT
Neuropeptide signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of appetiteISS:HGNC-UCL
Positive regulation of cell population proliferationIEA:Ensembl
Positive regulation of cell-substrate adhesionIEA:Ensembl
Positive regulation of dopamine metabolic processIEA:Ensembl
Positive regulation of eating behaviorIEA:Ensembl
Positive regulation of ERK1 and ERK2 cascadeIEA:Ensembl
Positive regulation of nitric oxide metabolic processIEA:Ensembl
Regulation of nerve growth factor productionIEA:Ensembl
Response to yeastIDA:UniProtKB
Sensory perception of tasteIEA:Ensembl
Short-day photoperiodismIEA:Ensembl
Cellular Location
Secreted
Cytoplasmic vesicle, secretory vesicle, neuronal dense core vesicle
PTM
The neuropeptide Y form is cleaved at Pro-30 by the prolyl endopeptidase FAP (seprase) activity (in vitro).

McDowell, K., Adamson, C., Jackson, C., Campbell, R., Welsh, P., Petrie, M. C., ... & Herring, N. (2024). Neuropeptide Y is elevated in heart failure and is an independent predictor of outcomes. European Journal of Heart Failure, 26(1), 107-116.

Bale, R., & Doshi, G. (2023). Cross talk about the role of Neuropeptide Y in CNS disorders and diseases. Neuropeptides, 102388.

Park, C., Kim, J., Ko, S. B., Choi, Y. K., Jeong, H., Woo, H., ... & Choi, H. J. (2022). Structural basis of neuropeptide Y signaling through Y1 receptor. Nature communications, 13(1), 853.

Zhang, Y., Liu, C. Y., Chen, W. C., Shi, Y. C., Wang, C. M., Lin, S., & He, H. F. (2021). Regulation of neuropeptide Y in body microenvironments and its potential application in therapies: A review. Cell & Bioscience, 11, 1-14.

Tanaka, M., Yamada, S., & Watanabe, Y. (2021). The role of neuropeptide Y in the nucleus accumbens. International Journal of Molecular Sciences, 22(14), 7287.

Assan, D., Mustapha, U. F., Chen, H., Li, Z., Peng, Y., & Li, G. (2021). The roles of neuropeptide Y (Npy) and peptide YY (Pyy) in teleost food intake: a mini review. Life, 11(6), 547.

Chen, W. C., Liu, Y. B., Liu, W. F., Zhou, Y. Y., He, H. F., & Lin, S. (2020). Neuropeptide Y is an immunomodulatory factor: direct and indirect. Frontiers in immunology, 11, 580378.

Shende, P., & Desai, D. (2020). Physiological and therapeutic roles of neuropeptide Y on biological functions. Cell Biology and Translational Medicine, Volume 7: Stem Cells and Therapy: Emerging Approaches, 37-47.

Corder, K. M., Li, Q., Cortes, M. A., Bartley, A. F., Davis, T. R., & Dobrunz, L. E. (2020). Overexpression of neuropeptide Y decreases responsiveness to neuropeptide Y. Neuropeptides, 79, 101979.

Li, C., Wu, X., Liu, S., Zhao, Y., Zhu, J., & Liu, K. (2019). Roles of neuropeptide Y in neurodegenerative and neuroimmune diseases. Frontiers in Neuroscience, 13, 869.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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