NPY

This gene encodes a neuropeptide that is widely expressed in the central nervous system and influences many physiological processes, including cortical excitability, stress response, food intake, circadian rhythms, and cardiovascular function. The neuropeptide functions through G protein-coupled receptors to inhibit adenylyl cyclase, activate mitogen-activated protein kinase (MAPK), regulate intracellular calcium levels, and activate potassium channels. A polymorphism in this gene resulting in a change of leucine 7 to proline in the signal peptide is associated with elevated cholesterol levels, higher alcohol consumption, and may be a risk factor for various metabolic and cardiovascular diseases. The protein also exhibits antimicrobial activity against bacteria and fungi. [provided by RefSeq, Oct 2014]

Neuropeptide Y

NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone.

Adult feeding behaviorISS:HGNC-UCL
AgingIEA:Ensembl
Antibacterial humoral responseIDA:UniProtKB
Antifungal humoral responseIDA:UniProtKB
Antimicrobial humoral immune response mediated by antimicrobial peptideIDA:UniProtKB
Central nervous system neuron developmentManual Assertion Based On ExperimentIEP:DFLAT
Cerebral cortex developmentManual Assertion Based On ExperimentIEP:DFLAT
Chemical synaptic transmissionManual Assertion Based On ExperimentTAS:ProtInc
Defense response to Gram-negative bacteriumIDA:UniProtKB
Defense response to Gram-positive bacteriumIDA:UniProtKB
Feeding behaviorManual Assertion Based On ExperimentIBA:GO_Central
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerManual Assertion Based On ExperimentTAS:ProtInc
Innate immune responseIDA:UniProtKB
Intestinal epithelial cell differentiationManual Assertion Based On ExperimentTAS:GO_Central
Monocyte activationIEA:Ensembl
Negative regulation of acute inflammatory response to antigenic stimulusIEA:Ensembl
Negative regulation of blood pressureIEA:Ensembl
Negative regulation of neuron deathIEA:Ensembl
Neuron projection developmentManual Assertion Based On ExperimentIEP:DFLAT
Neuropeptide signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of appetiteISS:HGNC-UCL
Positive regulation of cell population proliferationIEA:Ensembl
Positive regulation of cell-substrate adhesionIEA:Ensembl
Positive regulation of dopamine metabolic processIEA:Ensembl
Positive regulation of eating behaviorIEA:Ensembl
Positive regulation of ERK1 and ERK2 cascadeIEA:Ensembl
Positive regulation of nitric oxide metabolic processIEA:Ensembl
Regulation of nerve growth factor productionIEA:Ensembl
Response to yeastIDA:UniProtKB
Sensory perception of tasteIEA:Ensembl
Short-day photoperiodismIEA:Ensembl

Secreted
Cytoplasmic vesicle, secretory vesicle, neuronal dense core vesicle

The neuropeptide Y form is cleaved at Pro-30 by the prolyl endopeptidase FAP (seprase) activity (in vitro).