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Mouse Anti-NUDC Recombinant Antibody (6F12) (CBMAB-N3857-WJ)

This product is a Mouse antibody that recognizes NUDC. The antibody 6F12 can be used for immunoassay techniques such as: ELISA, WB.
See all NUDC antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
6F12
Antibody Isotype
IgG1, κ
Application
ELISA, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
nuclear distribution gene C homolog (A. nidulans)
Introduction
This gene encodes a nuclear distribution protein that plays an essential role in mitosis and cytokinesis. The encoded protein is involved in spindle formation during mitosis and in microtubule organization during cytokinesis. Pseudogenes of this gene are found on chromosome 2. [provided by RefSeq, Feb 2012]
Entrez Gene ID
10726
UniProt ID
Q9Y266
Alternative Names
Nuclear Distribution C, Dynein Complex Regulator; Nuclear Distribution Protein C Homolog; NudC Nuclear Distribution Protein; Nuclear Distribution Gene C Homolog (A. Nidulans); Nuclear Distribution C Homolog (A. Nidulans); Nuclear Distribution Gene C Homolog;
Function
Plays a role in neurogenesis and neuronal migration (By similarity).
Necessary for correct formation of mitotic spindles and chromosome separation during mitosis (PubMed:12852857, PubMed:12679384, PubMed:25789526).
Necessary for cytokinesis and cell proliferation (PubMed:12852857, PubMed:12679384).
Biological Process
Cell divisionIEA:UniProtKB-KW
Mitotic metaphase plate congressionManual Assertion Based On ExperimentIMP:UniProtKB
Mitotic spindle organizationManual Assertion Based On ExperimentIMP:UniProtKB
Nuclear migrationIEA:Ensembl
Protein foldingManual Assertion Based On ExperimentIBA:GO_Central
Response to peptide hormoneIEA:Ensembl
Cellular Location
Cytoplasm, cytoskeleton
Nucleus
Cytoplasm, cytoskeleton, spindle
Midbody
In a filamentous pattern adjacent to the nucleus of migrating cerebellar granule cells. Colocalizes with tubulin and dynein and with the microtubule organizing center. Distributed throughout the cytoplasm of non-migrating cells. A small proportion is nuclear, in a punctate pattern. Localizes to the mitotic spindle in a EML4-dependent manner (PubMed:25789526).
PTM
Reversibly phosphorylated on serine residues during the M phase of the cell cycle. Phosphorylation on Ser-274 and Ser-326 is necessary for correct formation of mitotic spindles and chromosome separation during mitosis. Phosphorylated by PLK and other kinases.

Vassileva, V., Georgieva, M., Todorov, D., & Mishev, K. (2023). Small Sized Yet Powerful: Nuclear Distribution C Proteins in Plants. Plants, 13(1), 119.

Garner, M. A., Hubbard, M. G., Boitet, E. R., Hubbard, S. T., Gade, A., Ying, G., ... & Gross, A. K. (2023). NUDC is critical for rod photoreceptor function, maintenance, and survival. bioRxiv, 2023-11.

Levi, H. J., Hubbard, M., Garner, M. A., Hollingsworth, T. J., Jiang, K., Nelson, N., ... & Gross, A. K. (2022). Dynein Dysregulation Due to the Absence of NUDC leads to Mitochondrial Mislocalization and Dysfunction in Rod Photoreceptors. Investigative Ophthalmology & Visual Science, 63(7), 3878-A0080.

Kawano, D., Pinter, K., Chlebowski, M., Petralia, R. S., Wang, Y. X., Nechiporuk, A. V., & Drerup, C. M. (2022). NudC regulated Lis1 stability is essential for the maintenance of dynamic microtubule ends in axon terminals. Iscience, 25(10).

Islam, M. A., Choi, H. J., Dash, R., Sharif, S. R., Oktaviani, D. F., Seog, D. H., & Moon, I. S. (2020). N-acetyl-D-Glucosamine kinase interacts with NudC and Lis1 in dynein motor complex and promotes cell migration. International Journal of Molecular Sciences, 22(1), 129.

Gross, A. K., Boitet, E. R., Reish, N. J., Benefield, D., Ying, G., Baehr, W., ... & Hubbard, M. (2020). NUDC is critical for regulation of photoreceptor cytoskeletal network. Investigative Ophthalmology & Visual Science, 61(7), 1121-1121.

Boitet, E. R., Reish, N. J., Hubbard, M. G., & Gross, A. K. (2019). NudC regulates photoreceptor disk morphogenesis and rhodopsin localization. The FASEB Journal, 33(8), 8799.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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