NUDC

NudC was first identified as a regulator of nuclear movement in the asexual reproductive cycle of the filamentous fungus Aspergillus nidulans. Human NUDC is a nuclear movement protein that associates with dynein (see DYNC1H1; MIM 600112) (Aumais et al., 2003 [PubMed 12679384]).[supplied by OMIM

Full Name

nuclear distribution gene C homolog (A. nidulans)

Function

Plays a role in neurogenesis and neuronal migration (By similarity).
Necessary for correct formation of mitotic spindles and chromosome separation during mitosis (PubMed:12852857, PubMed:12679384, PubMed:25789526).
Necessary for cytokinesis and cell proliferation (PubMed:12852857, PubMed:12679384).

Biological Process

Cell divisionIEA:UniProtKB-KW
Mitotic metaphase plate congressionManual Assertion Based On ExperimentIMP:UniProtKB
Mitotic spindle organizationManual Assertion Based On ExperimentIMP:UniProtKB
Nuclear migrationIEA:Ensembl
Protein foldingManual Assertion Based On ExperimentIBA:GO_Central
Response to peptide hormoneIEA:Ensembl

Cellular Location

Cytoplasm, cytoskeleton
Nucleus
Cytoplasm, cytoskeleton, spindle
Midbody
In a filamentous pattern adjacent to the nucleus of migrating cerebellar granule cells. Colocalizes with tubulin and dynein and with the microtubule organizing center. Distributed throughout the cytoplasm of non-migrating cells. A small proportion is nuclear, in a punctate pattern. Localizes to the mitotic spindle in a EML4-dependent manner (PubMed:25789526).

PTM

Reversibly phosphorylated on serine residues during the M phase of the cell cycle. Phosphorylation on Ser-274 and Ser-326 is necessary for correct formation of mitotic spindles and chromosome separation during mitosis. Phosphorylated by PLK and other kinases.