Rabbit Anti-OPRD1 Recombinant Antibody (
7G7) (V2LY-0725-LY1514)

Opioid Receptor Delta 1

G-protein coupled receptor that functions as receptor for endogenous enkephalins and for a subset of other opioids. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain and in opiate-mediated analgesia. Plays a role in developing analgesic tolerance to morphine.

Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathwayIEA:Ensembl
Adult locomotory behaviorIEA:Ensembl
Cellular response to growth factor stimulusIEA:Ensembl
Cellular response to hypoxiaManual Assertion Based On ExperimentIDA:ParkinsonsUK-UCL
Cellular response to toxic substanceManual Assertion Based On ExperimentIDA:ParkinsonsUK-UCL
Eating behaviorIEA:Ensembl
G protein-coupled opioid receptor signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerManual Assertion Based On ExperimentTAS:ProtInc
Immune responseManual Assertion Based On ExperimentTAS:ProtInc
Negative regulation of gene expressionManual Assertion Based On ExperimentIDA:ParkinsonsUK-UCL
Negative regulation of protein-containing complex assemblyManual Assertion Based On ExperimentIDA:ParkinsonsUK-UCL
Neuropeptide signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Phospholipase C-activating G protein-coupled receptor signaling pathwayISS:UniProtKB
Positive regulation of CREB transcription factor activity1 PublicationIC:ParkinsonsUK-UCL
Positive regulation of peptidyl-serine phosphorylationManual Assertion Based On ExperimentIDA:ParkinsonsUK-UCL
Regulation of calcium ion transportIEA:Ensembl
Regulation of mitochondrial membrane potentialManual Assertion Based On ExperimentIDA:ParkinsonsUK-UCL
Regulation of sensory perception of painIEA:Ensembl

Cell membrane

Extracellular: 1-47
Helical: 48-75
Cytoplasmic: 76-85
Helical: 86-110
Extracellular: 111-122
Helical: 123-144
Cytoplasmic: 145-163
Helical: 164-186
Extracellular: 187-206
Helical: 207-238
Cytoplasmic: 239-261
Helical: 262-284
Extracellular: 285-299
Helical: 300-321
Cytoplasmic: 322-372

N-glycosylated.
Ubiquitinated. A basal ubiquitination seems not to be related to degradation. Ubiquitination is increased upon formation of OPRM1:OPRD1 oligomers leading to proteasomal degradation; the ubiquitination is diminished by RTP4.