OPRD1

OPRD1 (Opioid Receptor Delta 1) is a protein coding gene. Diseases associated with OPRD1 include Heroin Dependence and Neonatal Abstinence Syndrome. Among its related pathways are Cytokine Signaling in Immune system and Innate Immune System. It has proved that the protein has G-protein coupled receptor activity and opioid receptor activity. And a paralog is OPRM1.

Full Name

Opioid Receptor Delta 1

Function

G-protein coupled receptor that functions as receptor for endogenous enkephalins and for a subset of other opioids. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain and in opiate-mediated analgesia. Plays a role in developing analgesic tolerance to morphine.

Biological Process

Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathwayIEA:Ensembl
Adult locomotory behaviorIEA:Ensembl
Cellular response to growth factor stimulusIEA:Ensembl
Cellular response to hypoxiaManual Assertion Based On ExperimentIDA:ParkinsonsUK-UCL
Cellular response to toxic substanceManual Assertion Based On ExperimentIDA:ParkinsonsUK-UCL
Eating behaviorIEA:Ensembl
G protein-coupled opioid receptor signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerManual Assertion Based On ExperimentTAS:ProtInc
Immune responseManual Assertion Based On ExperimentTAS:ProtInc
Negative regulation of gene expressionManual Assertion Based On ExperimentIDA:ParkinsonsUK-UCL
Negative regulation of protein-containing complex assemblyManual Assertion Based On ExperimentIDA:ParkinsonsUK-UCL
Neuropeptide signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Phospholipase C-activating G protein-coupled receptor signaling pathwayISS:UniProtKB
Positive regulation of CREB transcription factor activity1 PublicationIC:ParkinsonsUK-UCL
Positive regulation of peptidyl-serine phosphorylationManual Assertion Based On ExperimentIDA:ParkinsonsUK-UCL
Regulation of calcium ion transportIEA:Ensembl
Regulation of mitochondrial membrane potentialManual Assertion Based On ExperimentIDA:ParkinsonsUK-UCL
Regulation of sensory perception of painIEA:Ensembl

Cellular Location

Cell membrane

Topology

Extracellular: 1-47
Helical: 48-75
Cytoplasmic: 76-85
Helical: 86-110
Extracellular: 111-122
Helical: 123-144
Cytoplasmic: 145-163
Helical: 164-186
Extracellular: 187-206
Helical: 207-238
Cytoplasmic: 239-261
Helical: 262-284
Extracellular: 285-299
Helical: 300-321
Cytoplasmic: 322-372

PTM

N-glycosylated.
Ubiquitinated. A basal ubiquitination seems not to be related to degradation. Ubiquitination is increased upon formation of OPRM1:OPRD1 oligomers leading to proteasomal degradation; the ubiquitination is diminished by RTP4.