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Mouse Anti-PDGFD Recombinant Antibody (4H2) (CBMAB-P1256-YC)

Provided herein is a Mouse monoclonal antibody against Human Platelet Derived Growth Factor D. The antibody can be used for immunoassay techniques, such as ELISA, IP.
See all PDGFD antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
4H2
Antibody Isotype
IgG2b, κ
Application
ELISA, IP

Basic Information

Immunogen
PDGFD (NP_149126, 24-123 aa) partial recombinant protein with GST tag. Immunogen sequence: TPQSASIKAL RNANLRRDDL YRRDETIQVK GNGYVQSPRF PNSYPRNLLL TWRLHSQENT RIQLVFDNQF GLEEAENDIC RYDFVEVEDI SETSTIIRGR
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 24-123

Target

Full Name
platelet derived growth factor D
Introduction
PDGFD is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a core motif of eight cysteines, seven of which are found in this factor. This gene product only forms homodimers and, therefore, does not dimerize with the other three family members. It differs from alpha and beta members of this family in having an unusual N-terminal domain, the CUB domain. Two splice variants have been identified for this gene.
Entrez Gene ID
80310
UniProt ID
Q9GZP0
Alternative Names
Platelet Derived Growth Factor D; Spinal Cord-Derived Growth Factor B; Iris-Expressed Growth Factor; SCDGF-B; PDGF-D; SCDGFB;
Function
Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Plays an important role in wound healing. Induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis. Can initiate events that lead to a mesangial proliferative glomerulonephritis, including influx of monocytes and macrophages and production of extracellular matrix (By similarity).
Biological Process
Cellular response to amino acid stimulusIEA:Ensembl
Cellular response to hydrogen peroxideIEA:Ensembl
Cellular response to platelet-derived growth factor stimulusIEA:Ensembl
Cellular response to transforming growth factor beta stimulusIEA:Ensembl
Platelet-derived growth factor receptor signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of cell divisionIEA:UniProtKB-KW
Positive regulation of cell migrationManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of cell population proliferationManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of ERK1 and ERK2 cascadeManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of fibroblast proliferationIEA:Ensembl
Positive regulation of glomerular mesangial cell proliferationIEA:Ensembl
Positive regulation of MAP kinase activityManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of monocyte extravasationIEA:Ensembl
Positive regulation of phosphatidylinositol 3-kinase signalingManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of protein autophosphorylationManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of smooth muscle cell chemotaxisIEA:Ensembl
Positive regulation of smooth muscle cell proliferationIEA:Ensembl
Regulation of peptidyl-tyrosine phosphorylationIEA:Ensembl
Cellular Location
Secreted
Released by platelets upon wounding.
PTM
Activated by proteolytic cleavage. Proteolytic removal of the N-terminal CUB domain releasing the core domain is necessary for unmasking the receptor-binding epitopes of the core domain. Cleavage after Arg-247 or Arg-249 by urokinase plasminogen activator gives rise to the active form.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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