PDGFD

The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a core motif of eight cysteines, seven of which are found in this factor. This gene product only forms homodimers and, therefore, does not dimerize with the other three family members. It differs from alpha and beta members of this family in having an unusual N-terminal domain, the CUB domain. Two splice variants have been identified for this gene. [provided by RefSeq]

Full Name

platelet derived growth factor D

Function

Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Plays an important role in wound healing. Induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis. Can initiate events that lead to a mesangial proliferative glomerulonephritis, including influx of monocytes and macrophages and production of extracellular matrix (By similarity).

Biological Process

Cellular response to amino acid stimulusIEA:Ensembl
Cellular response to hydrogen peroxideIEA:Ensembl
Cellular response to platelet-derived growth factor stimulusIEA:Ensembl
Cellular response to transforming growth factor beta stimulusIEA:Ensembl
Platelet-derived growth factor receptor signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of cell divisionIEA:UniProtKB-KW
Positive regulation of cell migrationManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of cell population proliferationManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of ERK1 and ERK2 cascadeManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of fibroblast proliferationIEA:Ensembl
Positive regulation of glomerular mesangial cell proliferationIEA:Ensembl
Positive regulation of MAP kinase activityManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of monocyte extravasationIEA:Ensembl
Positive regulation of phosphatidylinositol 3-kinase signalingManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of protein autophosphorylationManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of smooth muscle cell chemotaxisIEA:Ensembl
Positive regulation of smooth muscle cell proliferationIEA:Ensembl
Regulation of peptidyl-tyrosine phosphorylationIEA:Ensembl

Cellular Location

Secreted
Released by platelets upon wounding.

PTM

Activated by proteolytic cleavage. Proteolytic removal of the N-terminal CUB domain releasing the core domain is necessary for unmasking the receptor-binding epitopes of the core domain. Cleavage after Arg-247 or Arg-249 by urokinase plasminogen activator gives rise to the active form.