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Mouse Anti-PELO Recombinant Antibody (G-4) (CBMAB-P1438-YC)

Provided herein is a Mouse monoclonal antibody against Human Pelota MRNA Surveillance And Ribosome Rescue Factor. The antibody can be used for immunoassay techniques, such as WB, IP, IF, ELISA.
See all PELO antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
G-4
Antibody Isotype
IgG
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
pelota homolog (Drosophila)
Introduction
PELO is a protein which contains a conserved nuclear localization signal. The encoded protein may have a role in spermatogenesis, cell cycle control, and in meiotic cell division.
Entrez Gene ID
UniProt ID
Alternative Names
Pelota MRNA Surveillance And Ribosome Rescue Factor; Pelota (Drosophila) Homolog; Pelota Homolog (Drosophila); Protein Pelota Homolog; Pelota Homolog; EC 3.1.-.-; PRO1770; CGI-17;
Function
Cotranslational quality control factor involved in the No-Go Decay (NGD) pathway (PubMed:21448132, PubMed:29861391).
In the presence of ABCE1 and HBS1L, is required for 48S complex formation from 80S ribosomes and dissociation of vacant 80S ribosomes (PubMed:21448132).
Together with HBS1L and in presence of ABCE1, recognizes stalled ribosomes and promotes dissociation of elongation complexes assembled on non-stop mRNAs; this triggers endonucleolytic cleavage of the mRNA, a mechanism to release non-functional ribosomes and to degrade damaged mRNAs as part of the No-Go Decay (NGD) pathway (PubMed:21448132).
As part of the PINK1-regulated signaling, upon mitochondrial damage is recruited to the ribosome/mRNA-ribonucleoprotein complex associated to mitochondrial outer membrane thereby enabling the recruitment of autophagy receptors and induction of mitophagy (PubMed:29861391).
Biological Process
Cell cycleIEA:UniProtKB-KW
Cell divisionIEA:UniProtKB-KW
Chromosome organizationIEA:Ensembl
Endoderm developmentIEA:Ensembl
Inner cell mass cell proliferationIEA:Ensembl
Mesenchymal to epithelial transitionIEA:Ensembl
Nonfunctional rRNA decayManual Assertion Based On ExperimentIBA:GO_Central
Nuclear-transcribed mRNA catabolic process, no-go decayManual Assertion Based On ExperimentIBA:GO_Central
Nuclear-transcribed mRNA catabolic process, non-stop decayIEA:InterPro
Positive regulation of BMP signaling pathwayIEA:Ensembl
Regulation of translationIEA:UniProtKB-KW
Ribosome disassemblyManual Assertion Based On ExperimentIBA:GO_Central
RNA surveillanceIEA:InterPro
Stem cell population maintenanceIEA:Ensembl
Cellular Location
Nucleus
Cytoplasm
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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