Mouse Anti-PELO Recombinant Antibody (G-4) (CBMAB-P1438-YC)
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Basic Information
Formulations & Storage [For reference only, actual COA shall prevail!]
Target
In the presence of ABCE1 and HBS1L, is required for 48S complex formation from 80S ribosomes and dissociation of vacant 80S ribosomes (PubMed:21448132).
Together with HBS1L and in presence of ABCE1, recognizes stalled ribosomes and promotes dissociation of elongation complexes assembled on non-stop mRNAs; this triggers endonucleolytic cleavage of the mRNA, a mechanism to release non-functional ribosomes and to degrade damaged mRNAs as part of the No-Go Decay (NGD) pathway (PubMed:21448132).
As part of the PINK1-regulated signaling, upon mitochondrial damage is recruited to the ribosome/mRNA-ribonucleoprotein complex associated to mitochondrial outer membrane thereby enabling the recruitment of autophagy receptors and induction of mitophagy (PubMed:29861391).
Cell divisionIEA:UniProtKB-KW
Chromosome organizationIEA:Ensembl
Endoderm developmentIEA:Ensembl
Inner cell mass cell proliferationIEA:Ensembl
Mesenchymal to epithelial transitionIEA:Ensembl
Nonfunctional rRNA decayManual Assertion Based On ExperimentIBA:GO_Central
Nuclear-transcribed mRNA catabolic process, no-go decayManual Assertion Based On ExperimentIBA:GO_Central
Nuclear-transcribed mRNA catabolic process, non-stop decayIEA:InterPro
Positive regulation of BMP signaling pathwayIEA:Ensembl
Regulation of translationIEA:UniProtKB-KW
Ribosome disassemblyManual Assertion Based On ExperimentIBA:GO_Central
RNA surveillanceIEA:InterPro
Stem cell population maintenanceIEA:Ensembl
Cytoplasm
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Please try the standard protocols which include: protocols, troubleshooting and guide.
Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols
Custom Antibody Labeling
We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).
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