PELO

This gene encodes a protein which contains a conserved nuclear localization signal. The encoded protein may have a role in spermatogenesis, cell cycle control, and in meiotic cell division. [provided by RefSeq]

Full Name

pelota homolog (Drosophila)

Function

Cotranslational quality control factor involved in the No-Go Decay (NGD) pathway (PubMed:21448132, PubMed:29861391).
In the presence of ABCE1 and HBS1L, is required for 48S complex formation from 80S ribosomes and dissociation of vacant 80S ribosomes (PubMed:21448132).
Together with HBS1L and in presence of ABCE1, recognizes stalled ribosomes and promotes dissociation of elongation complexes assembled on non-stop mRNAs; this triggers endonucleolytic cleavage of the mRNA, a mechanism to release non-functional ribosomes and to degrade damaged mRNAs as part of the No-Go Decay (NGD) pathway (PubMed:21448132).
As part of the PINK1-regulated signaling, upon mitochondrial damage is recruited to the ribosome/mRNA-ribonucleoprotein complex associated to mitochondrial outer membrane thereby enabling the recruitment of autophagy receptors and induction of mitophagy (PubMed:29861391).

Biological Process

Cell cycleIEA:UniProtKB-KW
Cell divisionIEA:UniProtKB-KW
Chromosome organizationIEA:Ensembl
Endoderm developmentIEA:Ensembl
Inner cell mass cell proliferationIEA:Ensembl
Mesenchymal to epithelial transitionIEA:Ensembl
Nonfunctional rRNA decayManual Assertion Based On ExperimentIBA:GO_Central
Nuclear-transcribed mRNA catabolic process, no-go decayManual Assertion Based On ExperimentIBA:GO_Central
Nuclear-transcribed mRNA catabolic process, non-stop decayIEA:InterPro
Positive regulation of BMP signaling pathwayIEA:Ensembl
Regulation of translationIEA:UniProtKB-KW
Ribosome disassemblyManual Assertion Based On ExperimentIBA:GO_Central
RNA surveillanceIEA:InterPro
Stem cell population maintenanceIEA:Ensembl

Cellular Location

Nucleus
Cytoplasm