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Mouse Anti-PKLR Recombinant Antibody (1C7) (CBMAB-P1929-YC)

Provided herein is a Mouse monoclonal antibody against Human Pyruvate kinase L/R. The antibody can be used for immunoassay techniques, such as FC, ICC, IF, WB.
See all PKLR antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1C7
Antibody Isotype
IgG2b
Application
FC, ICC, IF, WB

Basic Information

Immunogen
Full length human recombinant protein of human PKLR (NP_000289) produced in HEK293T cell
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
PBS, pH 7.3, 1% BSA, 50% glycerol, 0.02% sodium azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
pyruvate kinase, liver and RBC
Introduction
PKLR is a pyruvate kinase that catalyzes the transphosphorylation of phohsphoenolpyruvate into pyruvate and ATP, which is the rate-limiting step of glycolysis. Defects in this enzyme, due to gene mutations or genetic variations, are the common cause of chronic hereditary nonspherocytic hemolytic anemia (CNSHA or HNSHA).
Entrez Gene ID
5313
UniProt ID
P30613
Alternative Names
PK1; PKL; PKR; PKRL; RPK
Function
Pyruvate kinase that catalyzes the conversion of phosphoenolpyruvate to pyruvate with the synthesis of ATP, and which plays a key role in glycolysis.
Biological Process
ATP biosynthetic processIEA:Ensembl
Cellular response to epinephrine stimulusIEA:Ensembl
Cellular response to insulin stimulusManual Assertion Based On ExperimentIBA:GO_Central
Glycolytic processManual Assertion Based On ExperimentIBA:GO_Central
Pyruvate biosynthetic processIEA:Ensembl
Response to ATPIEA:Ensembl
Response to cAMPIEA:Ensembl
Response to glucoseIEA:Ensembl
Response to heatIEA:Ensembl
Response to hypoxiaIEA:Ensembl
Response to lithium ionIEA:Ensembl
Response to nutrientIEA:Ensembl
Cellular Location
cytoplasm
cytosol
extracellular exosome
Involvement in disease
Pyruvate kinase hyperactivity (PKHYP):
Autosomal dominant phenotype characterized by increase of red blood cell ATP.
Pyruvate kinase deficiency of red cells (PKRD):
A frequent cause of hereditary non-spherocytic hemolytic anemia. Clinically, pyruvate kinase-deficient patients suffer from a highly variable degree of chronic hemolysis, ranging from severe neonatal jaundice and fatal anemia at birth, severe transfusion-dependent chronic hemolysis, moderate hemolysis with exacerbation during infection, to a fully compensated hemolysis without apparent anemia.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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