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Mouse Anti-PRDM8 Recombinant Antibody (E-3) (CBMAB-P2722-YC)

Provided herein is a Mouse monoclonal antibody against Human PR/SET Domain 8. The antibody can be used for immunoassay techniques, such as WB, IP, IF, ELISA.
See all PRDM8 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
E-3
Antibody Isotype
IgG
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
PR/SET Domain 8
Introduction
PRDM8 is a protein that belongs to a conserved family of histone methyltransferases that predominantly act as negative regulators of transcription. The encoded protein contains an N-terminal Su(var)3-9, Enhancer-of-zeste, and Trithorax (SET) domain and a double zinc-finger domain. Knockout of this gene in mouse results in mistargeting by neurons of the dorsal telencephalon, abnormal itch-like behavior, and impaired differentiation of rod bipolar cells. In humans, the protein has been shown to interact with the phosphatase laforin and the ubiquitin ligase malin, which regulate glycogen construction in the cytoplasm.
Entrez Gene ID
Human56978
Mouse77630
Rat305198
UniProt ID
HumanQ9NQV8
MouseQ8BZ97
RatD4A123
Alternative Names
EPM10; PFM5
Function
Probable histone methyltransferase, preferentially acting on 'Lys-9' of histone H3 (By similarity).
Involved in the control of steroidogenesis through transcriptional repression of steroidogenesis marker genes such as CYP17A1 and LHCGR (By similarity).
Forms with BHLHE22 a transcriptional repressor complex controlling genes involved in neural development and neuronal differentiation (By similarity).
In the retina, it is required for rod bipolar and type 2 OFF-cone bipolar cell survival (By similarity).
Biological Process
MethylationIEA:UniProtKB-KW
Oligodendrocyte developmentManual Assertion Based On ExperimentIBA:GO_Central
Regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Nucleus
Involvement in disease
Epilepsy, progressive myoclonic 10 (EPM10):
A form of progressive myoclonic epilepsy, a clinically and genetically heterogeneous group of disorders defined by the combination of action and reflex myoclonus, other types of epileptic seizures, and progressive neurodegeneration and neurocognitive impairment. EPM10 is an autosomal recessive form characterized by progressive dysarthria, myoclonus, ataxia, cognitive decline, psychosis, dementia and spasticity, with onset in childhood. There is variability between patients.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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