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Mouse Anti-PRPH Recombinant Antibody (CBMAB-BR405LY)

The product is antibody recognizes PRPH. The antibody immunoassay techniques such as: IF, IHC, WB.
See all PRPH antibodies

Summary

Host Animal
Mouse
Specificity
Rat, Cattle, Human, Mouse, Pig
Antibody Isotype
IgG
Application
IF: 1:1000 dilution, IHC: 1:300-1:500 dilution, WB: 0.1-0.5 μg/ml

Basic Information

Immunogen
Recombinant rat peripherin purified from E. coli
Specificity
Rat, Cattle, Human, Mouse, Pig
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
50% glycerol
Preservative
5mM sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
peripherin
Entrez Gene ID
Human5630
Mouse19132
Rat24688
Cattle510082
Pig100152434
UniProt ID
HumanP41219
MouseP15331
RatP21807
CattleP17810
PigF1SHC0
Alternative Names
Peripherin;Neurofilament 4;PRPH;NEF4, PRPH1;
Function
Class-III neuronal intermediate filament protein (By similarity).
May form an independent structural network without the involvement of other neurofilaments or may cooperate with the neuronal intermediate filament proteins NEFL, NEFH, NEFM and INA to form a filamentous network (PubMed:15446584, PubMed:15322088).
Assembly of the neuronal intermediate filaments may be regulated by RAB7A (By similarity).
Plays a role in the development of unmyelinated sensory neurons (By similarity).
May be involved in axon elongation and axon regeneration after injury (By similarity).
Inhibits neurite extension in type II spiral ganglion neurons in the cochlea (By similarity).
Biological Process
Intermediate filament organizationManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cytoplasm, cytoskeleton
Cell projection, axon
Perikaryon
Involvement in disease
Amyotrophic lateral sclerosis (ALS):
A neurodegenerative disorder affecting upper motor neurons in the brain and lower motor neurons in the brain stem and spinal cord, resulting in fatal paralysis. Sensory abnormalities are absent. The pathologic hallmarks of the disease include pallor of the corticospinal tract due to loss of motor neurons, presence of ubiquitin-positive inclusions within surviving motor neurons, and deposition of pathologic aggregates. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of the cases.
PTM
Phosphorylated; phosphorylation increases after nerve injury in regenerating neurons.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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