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Mouse Anti-PRPH Recombinant Antibody (7C5) (CBMAB-1710-CN)

This product is a mouse antibody that recognizes PRPH of rat. The antibody 7C5 can be used for immunoassay techniques such as: IF, IHC-P, WB.
See all PRPH antibodies
Published Data
Fig.1 Conventional microscopic images of Type III Nrg1+ punctae (green) found along peripherin+ axons (blue) from WT and Type III Nrg1+/− sensory cultures. Scale bars equal 10 µm.
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Summary

Host Animal
Mouse
Specificity
Rat, Chicken
Clone
7C5
Antibody Isotype
IgG1
Application
IF, IHC-P, WB

Basic Information

Immunogen
Recombinant full length protein corresponding to Rat Peripherin
Specificity
Rat, Chicken
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
Tissue culture supernatant
Preservative
5mM Sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
peripherin
Introduction
Class-III neuronal intermediate filament protein. It contributes to the formation of intermediate filament networks.
Entrez Gene ID
Chicken101748212
Rat24688
UniProt ID
ChickenA0A1D5PFV7
RatP21807
Alternative Names
Perf; Prph1
Function
Class-III neuronal intermediate filament protein (By similarity).
May form an independent structural network without the involvement of other neurofilaments or may cooperate with the neuronal intermediate filament proteins NEFL, NEFH, NEFM and INA to form a filamentous network (PubMed:15446584, PubMed:15322088).
Assembly of the neuronal intermediate filaments may be regulated by RAB7A (By similarity).
Plays a role in the development of unmyelinated sensory neurons (By similarity).
May be involved in axon elongation and axon regeneration after injury (By similarity).
Inhibits neurite extension in type II spiral ganglion neurons in the cochlea (By similarity).
Biological Process
Intermediate filament organizationManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cytoplasm, cytoskeleton
Cell projection, axon
Perikaryon
Involvement in disease
Amyotrophic lateral sclerosis (ALS):
A neurodegenerative disorder affecting upper motor neurons in the brain and lower motor neurons in the brain stem and spinal cord, resulting in fatal paralysis. Sensory abnormalities are absent. The pathologic hallmarks of the disease include pallor of the corticospinal tract due to loss of motor neurons, presence of ubiquitin-positive inclusions within surviving motor neurons, and deposition of pathologic aggregates. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of the cases.
PTM
Phosphorylated; phosphorylation increases after nerve injury in regenerating neurons.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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