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Mouse Anti-PTPN13 Recombinant Antibody (CBYC-P779) (CBMAB-P3426-YC)

Provided herein is a Mouse monoclonal antibody against Human Protein tyrosine phosphatase, non-receptor type 13. The antibody can be used for immunoassay techniques, such as WB.
See all PTPN13 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYC-P779
Antibody Isotype
IgG2b
Application
WB

Basic Information

Immunogen
E. coli-derived Recombinant human PTPN13/PTPL1, His2-Arg500
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized from PBS with trehalose
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Protein tyrosine phosphatase, non-receptor type 13
Introduction
PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP is a large intracellular protein. It has a catalytic PTP domain at its C-terminus and two major structural domains: a region with five PDZ domains and a FERM domain that binds to plasma membrane and cytoskeletal elements. This PTP was found to interact with, and dephosphorylate, Fas receptor and IkappaBalpha through the PDZ domains. This suggests it has a role in Fas mediated programmed cell death.
Entrez Gene ID
5783
UniProt ID
Q12923
Alternative Names
hPTP1E; PTPLE; PNP1; PTP1E; PTP-BL; FAP-1; PTP-BAS; PTPL1
Function
Tyrosine phosphatase which regulates negatively FAS-induced apoptosis and NGFR-mediated pro-apoptotic signaling (PubMed:15611135).
May regulate phosphoinositide 3-kinase (PI3K) signaling through dephosphorylation of PIK3R2 (PubMed:23604317).
Biological Process
Negative regulation of protein phosphorylationManual Assertion Based On ExperimentIMP:UniProtKB
Peptidyl-tyrosine dephosphorylationManual Assertion Based On ExperimentIMP:UniProtKB
Protein dephosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of phosphatidylinositol 3-kinase signalingManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Cytoplasm, cytoskeleton
Nucleus
Cell projection, lamellipodium
Colocalizes with F-actin (PubMed:10826496).
Colocalizes with PKN2 in lamellipodia-like structure, regions of large actin turnover (PubMed:11356191).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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