PTPN13

PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP is a large intracellular protein. It has a catalytic PTP domain at its C-terminus and two major structural domains: a region with five PDZ domains and a FERM domain that binds to plasma membrane and cytoskeletal elements. This PTP was found to interact with, and dephosphorylate, Fas receptor and IkappaBalpha through the PDZ domains. This suggests it has a role in Fas mediated programmed cell death.

Full Name

Protein tyrosine phosphatase, non-receptor type 13

Function

Tyrosine phosphatase which regulates negatively FAS-induced apoptosis and NGFR-mediated pro-apoptotic signaling (PubMed:15611135).
May regulate phosphoinositide 3-kinase (PI3K) signaling through dephosphorylation of PIK3R2 (PubMed:23604317).

Biological Process

Negative regulation of protein phosphorylationManual Assertion Based On ExperimentIMP:UniProtKB
Peptidyl-tyrosine dephosphorylationManual Assertion Based On ExperimentIMP:UniProtKB
Protein dephosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of phosphatidylinositol 3-kinase signalingManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

Cytoplasm, cytoskeleton
Nucleus
Cell projection, lamellipodium
Colocalizes with F-actin (PubMed:10826496).
Colocalizes with PKN2 in lamellipodia-like structure, regions of large actin turnover (PubMed:11356191).