Sign in or Register   Sign in or Register
  |  

Mouse Anti-RHOG Recombinant Antibody (1F3-B3-E5) (CBMAB-R2586-CN)

This product is a Mouse antibody that recognizes RHOG. The antibody 1F3-B3-E5 can be used for immunoassay techniques such as: WB, ELISA.
See all RHOG antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
1F3-B3-E5
Antibody Isotype
IgG2b, κ
Application
WB, ELISA

Basic Information

Immunogen
KLH synthetic peptide encompassing aa. RhoG 161-180
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG2b, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Target

Full Name
Ras Homolog Family Member G
Introduction
This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The encoded protein facilitates translocation of a functional guanine nucleotide exchange factor (GEF) complex from the cytoplasm to the plasma membrane where ras-related C3 botulinum toxin substrate 1 is activated to promote lamellipodium formation and cell migration. Two related pseudogene have been identified on chromosomes 20 and X. [provided by RefSeq, Aug 2011]
Entrez Gene ID
Human391
Mouse56212
Rat308875
UniProt ID
HumanP84095
MouseP84096
RatQ32PX6
Alternative Names
Ras Homolog Family Member G; Ras Homolog Gene Family, Member G (Rho G); ARHG; Rho-Related GTP-Binding Protein RhoG;
Function
Required for the formation of membrane ruffles during macropinocytosis. Plays a role in cell migration and is required for the formation of cup-like structures during trans-endothelial migration of leukocytes. In case of Salmonella enterica infection, activated by SopB and ARHGEF26/SGEF, which induces cytoskeleton rearrangements and promotes bacterial entry.
Biological Process
Biological Process actin cytoskeleton organizationManual Assertion Based On ExperimentIDA:MGI
Biological Process actin filament organizationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process activation of GTPase activityManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process cell chemotaxisManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process cell projection assemblyManual Assertion Based On ExperimentIBA:GO_Central
Biological Process cortical cytoskeleton organizationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process engulfment of apoptotic cellManual Assertion Based On ExperimentIBA:GO_Central
Biological Process establishment or maintenance of cell polarityManual Assertion Based On ExperimentIBA:GO_Central
Biological Process motor neuron axon guidanceManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of cell population proliferationManual Assertion Based On ExperimentTAS:ProtInc
Biological Process positive regulation of protein localization to plasma membraneManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIDA:MGI
Biological Process Rac protein signal transductionManual Assertion Based On ExperimentIDA:MGI
Biological Process regulation of actin cytoskeleton organizationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of cell shapeManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of neutrophil migrationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of ruffle assemblyIEA:Ensembl
Biological Process Rho protein signal transductionManual Assertion Based On ExperimentIDA:MGI
Cellular Location
Cell membrane
PTM
(Microbial infection) Glucosylated at Thr-35 by C.difficile toxin TcdB.
(Microbial infection) Glycosylated (O-GlcNAcylated) at Thr-35 by C.novyi toxin TcdA (PubMed:8810274).
O-GlcNAcylation completely prevents the recognition of the downstream effector, blocking the GTPases in their inactive form, leading to actin cytoskeleton disruption (PubMed:8810274).
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-RHOG Recombinant Antibody (1F3-B3-E5)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare