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Mouse Anti-SAA1 Recombinant Antibody (mc1) (CBMAB-S6420-CQ)

This product is a mouse antibody that recognizes SAA1. The antibody mc1 can be used for immunoassay techniques such as: IHC, IHC-P, IHC-Fr.
See all SAA1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
mc1
Antibody Isotype
IgG2a
Application
IHC, IHC-P, IHC-Fr

Basic Information

Immunogen
Purified human amyloid A coupled to HRP and kininogen
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Serum Amyloid A1
Introduction
This gene encodes a member of the serum amyloid A family of apolipoproteins. The encoded preproprotein is proteolytically processed to generate the mature protein. This protein is a major acute phase protein that is highly expressed in response to inflammation and tissue injury. This protein also plays an important role in HDL metabolism and cholesterol homeostasis. High levels of this protein are associated with chronic inflammatory diseases including atherosclerosis, rheumatoid arthritis, Alzheimer's disease and Crohn's disease. This protein may also be a potential biomarker for certain tumors. Alternate splicing results in multiple transcript variants that encode the same protein. A pseudogene of this gene is found on chromosome 11.
Entrez Gene ID
UniProt ID
Alternative Names
Serum Amyloid A1; SAA; Tumor Protein P53 Inducible Protein 4; Serum Amyloid A-1 Protein; Serum Amyloid A Protein; TP53I4; PIG4; SAA2;
Function
Major acute phase protein.
Biological Process
Biological Process acute-phase responseIEA:UniProtKB-KW
Biological Process lymphocyte chemotaxisManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process macrophage chemotaxisManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of inflammatory response1 PublicationNAS:UniProtKB
Biological Process neutrophil chemotaxis1 PublicationNAS:UniProtKB
Biological Process platelet activation1 PublicationNAS:UniProtKB
Biological Process positive regulation of cell adhesionManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of cytokine productionManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of cytosolic calcium ion concentrationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of interleukin-1 production1 PublicationNAS:UniProtKB
Biological Process regulation of protein secretion1 PublicationNAS:UniProtKB
Cellular Location
Secreted
Involvement in disease
Reactive, secondary amyloidosis is characterized by the extracellular accumulation in various tissues of the SAA1 protein. These deposits are highly insoluble and resistant to proteolysis; they disrupt tissue structure and compromise function.
Elevated serum SAA1 protein levels may be associated with lung cancer.
PTM
This protein is the precursor of amyloid protein A, which is formed by the removal of approximately 24 residues from the C-terminal end.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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