SAA1

This gene encodes a member of the serum amyloid A family of apolipoproteins. The encoded preproprotein is proteolytically processed to generate the mature protein. This protein is a major acute phase protein that is highly expressed in response to inflammation and tissue injury. This protein also plays an important role in HDL metabolism and cholesterol homeostasis. High levels of this protein are associated with chronic inflammatory diseases including atherosclerosis, rheumatoid arthritis, Alzheimer's disease and Crohn's disease. This protein may also be a potential biomarker for certain tumors. Alternate splicing results in multiple transcript variants that encode the same protein. A pseudogene of this gene is found on chromosome 11. [provided by RefSeq, Feb 2016]
Full Name
Serum Amyloid A1
Function
Major acute phase protein.
Biological Process
Biological Process acute-phase responseIEA:UniProtKB-KW
Biological Process lymphocyte chemotaxisManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process macrophage chemotaxisManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of inflammatory response1 PublicationNAS:UniProtKB
Biological Process neutrophil chemotaxis1 PublicationNAS:UniProtKB
Biological Process platelet activation1 PublicationNAS:UniProtKB
Biological Process positive regulation of cell adhesionManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of cytokine productionManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of cytosolic calcium ion concentrationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of interleukin-1 production1 PublicationNAS:UniProtKB
Biological Process regulation of protein secretion1 PublicationNAS:UniProtKB
Cellular Location
Secreted
Involvement in disease
Reactive, secondary amyloidosis is characterized by the extracellular accumulation in various tissues of the SAA1 protein. These deposits are highly insoluble and resistant to proteolysis; they disrupt tissue structure and compromise function.
Elevated serum SAA1 protein levels may be associated with lung cancer.
PTM
This protein is the precursor of amyloid protein A, which is formed by the removal of approximately 24 residues from the C-terminal end.
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Anti-SAA1 antibodies

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Mouse Anti-SAA1 Recombinant Antibody (Reu86.1) (CBMAB-S6495-CQ)

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Target: SAA1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: Reu86.1
Application*: E, C, P, WB
Datasheet SDS

Mouse Anti-SAA1 Recombinant Antibody (CBT3989) (V2LY-0625-LY1454)

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Target: SAA1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT3989
Application*: IH, F
Datasheet SDS

Mouse Anti-SAA1 Recombinant Antibody (CBT3793) (V2LY-0625-LY1338)

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Target: SAA1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT3793
Application*: WB
Datasheet SDS

Mouse Anti-SAA1 Recombinant Antibody (CB321A) (CBMAB-CA321LY)

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Target: SAA1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CB321A
Application*: ELISA
Datasheet SDS

Recombinant Mouse Anti-SAA1 Antibody (CBHb185) (CBMAB-Hb957-LY)

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Target: SAA1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: CBHb185
Application*: IHC-F, Immuno assays, IHC-P, WB
Datasheet SDS

Recombinant Mouse Anti-SAA1 Antibody (CBHb184) (CBMAB-Hb956-LY)

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Target: SAA1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: CBHb184
Application*: IHC-F, Immuno assays, IHC-P, WB
Datasheet SDS

Mouse Anti-SAA1 Recombinant Antibody (1F2E1) (CBMAB-R4294-CN)

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Target: SAA1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 1F2E1
Application*: E
Datasheet SDS

Mouse Anti-SAA1 Recombinant Antibody (CBFYA-0115) (CBMAB-X0171-FY)

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Target: SAA1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: CBFYA-0115
Application*: C, IA, P, WB
Datasheet SDS

Mouse Anti-SAA1 Recombinant Antibody (S3-F11) (CBMAB-S6526-CQ)

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Target: SAA1
Host: Mouse
Antibody Isotype: IgM
Specificity: Human
Clone: S3-F11
Application*: E, WB
Datasheet SDS

Mouse Anti-SAA1 Recombinant Antibody (Reu86.5) (CBMAB-S6497-CQ)

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Target: SAA1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: Reu86.5
Application*: E, C, P, WB
Datasheet SDS

Mouse Anti-SAA1 Recombinant Antibody (Reu86.2) (CBMAB-S6496-CQ)

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Target: SAA1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: Reu86.2
Application*: E, IH
Datasheet SDS

Mouse Anti-SAA1 Recombinant Antibody (mcl) (CBMAB-S6424-CQ)

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Target: SAA1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: mcl
Application*: P
Datasheet SDS

Mouse Anti-SAA1 Recombinant Antibody (mc1) (CBMAB-S6420-CQ)

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Target: SAA1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: mc1
Application*: IH, P, C
Datasheet SDS

Mouse Anti-SAA1 Recombinant Antibody (CBXS-2431) (CBMAB-S5188-CQ)

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Target: SAA1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: CBXS-2431
Application*: E, IH, WB
Datasheet SDS

Mouse Anti-SAA1 Recombinant Antibody (CBXS-1971) (CBMAB-S4744-CQ)

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Target: SAA1
Host: Mouse
Antibody Isotype: IgG3
Specificity: Human
Clone: CBXS-1971
Application*: IH
Datasheet SDS

Mouse Anti-SAA1 Recombinant Antibody (CBXS-1970) (CBMAB-S4743-CQ)

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Target: SAA1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXS-1970
Application*: WB
Datasheet SDS

Rat Anti-SAA1 Recombinant Antibody (CBXS-1800) (CBMAB-S4613-CQ)

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Target: SAA1
Host: Rat
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-1800
Application*: WB
Datasheet SDS

Rabbit Anti-SAA1 Recombinant Antibody (CBXS-1176) (CBMAB-S4046-CQ)

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Target: SAA1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBXS-1176
Application*: WB, P
Datasheet SDS

Mouse Anti-SAA1 Recombinant Antibody (CBXS-0107) (CBMAB-S3102-CQ)

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Target: SAA1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBXS-0107
Application*: E, WB, P
Datasheet SDS

Mouse Anti-SAA1 Recombinant Antibody (CBXS-0106) (CBMAB-S3101-CQ)

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Target: SAA1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-0106
Application*: C, P
Datasheet SDS

Mouse Anti-SAA1 Recombinant Antibody (CBXS-0101) (CBMAB-S3100-CQ)

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Target: SAA1
Host: Mouse
Specificity: Human
Clone: CBXS-0101
Application*: WB, IC, P, C, E
Datasheet SDS

Mouse Anti-SAA1 Recombinant Antibody (CBXS-6123) (CBMAB-S2967-CQ)

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Target: SAA1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-6123
Application*: E, WB
Datasheet SDS

Rabbit Anti-SAA1 Recombinant Antibody (CBXS-5457) (CBMAB-S2667-CQ)

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Target: SAA1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBXS-5457
Application*: WB
Datasheet SDS

Mouse Anti-SAA1 Recombinant Antibody (CBXS-4794) (CBMAB-S2020-CQ)

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Target: SAA1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBXS-4794
Application*: E, WB
Datasheet SDS

Mouse Anti-SAA1 Recombinant Antibody (CBXS-3642) (CBMAB-S0922-CQ)

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Target: SAA1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-3642
Application*: E, WB
Datasheet SDS

Mouse Anti-SAA1 Recombinant Antibody (CBXS-5779) (CBMAB-S0638-CQ)

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Target: SAA1
Host: Mouse
Antibody Isotype: IgG2, κ
Specificity: Human
Clone: CBXS-5779
Application*: WB, E, P, SE
Datasheet SDS

Mouse Anti-SAA1 Recombinant Antibody (CBXS-5723) (CBMAB-S0587-CQ)

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Target: SAA1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBXS-5723
Application*: E, WB
Datasheet SDS

Mouse Anti-SAA1 Recombinant Antibody (SAA15) (CBMAB-S0080-CQ)

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Target: SAA1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: SAA15
Application*: WB, SE
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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