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SAA1

This gene encodes a member of the serum amyloid A family of apolipoproteins. The encoded preproprotein is proteolytically processed to generate the mature protein. This protein is a major acute phase protein that is highly expressed in response to inflammation and tissue injury. This protein also plays an important role in HDL metabolism and cholesterol homeostasis. High levels of this protein are associated with chronic inflammatory diseases including atherosclerosis, rheumatoid arthritis, Alzheimer's disease and Crohn's disease. This protein may also be a potential biomarker for certain tumors. Alternate splicing results in multiple transcript variants that encode the same protein. A pseudogene of this gene is found on chromosome 11. [provided by RefSeq, Feb 2016]

Full Name

Serum Amyloid A1

Function

Major acute phase protein.

Biological Process

Biological Process acute-phase responseIEA:UniProtKB-KW
Biological Process lymphocyte chemotaxisManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process macrophage chemotaxisManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of inflammatory response1 PublicationNAS:UniProtKB
Biological Process neutrophil chemotaxis1 PublicationNAS:UniProtKB
Biological Process platelet activation1 PublicationNAS:UniProtKB
Biological Process positive regulation of cell adhesionManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of cytokine productionManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of cytosolic calcium ion concentrationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of interleukin-1 production1 PublicationNAS:UniProtKB
Biological Process regulation of protein secretion1 PublicationNAS:UniProtKB

Cellular Location

Secreted

Involvement in disease

Reactive, secondary amyloidosis is characterized by the extracellular accumulation in various tissues of the SAA1 protein. These deposits are highly insoluble and resistant to proteolysis; they disrupt tissue structure and compromise function.
Elevated serum SAA1 protein levels may be associated with lung cancer.

PTM

This protein is the precursor of amyloid protein A, which is formed by the removal of approximately 24 residues from the C-terminal end.

Anti-SAA1 antibodies

Rabbit Anti-SAA1 Recombinant Antibody (CBXS-1176) (CBMAB-S4046-CQ)

SDS

Target: SAA1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: CBXS-1176

Application*: WB, P

Mouse Anti-SAA1 Recombinant Antibody (CBXS-2431) (CBMAB-S5188-CQ)

SDS

Target: SAA1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse

Clone: CBXS-2431

Application*: E, IH, WB

Mouse Anti-SAA1 Recombinant Antibody (CBFYA-0115) (CBMAB-X0171-FY)

SDS

Target: SAA1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse

Clone: CBFYA-0115

Application*: C, IA, P, WB

Mouse Anti-SAA1 Recombinant Antibody (SAA15) (CBMAB-S0080-CQ)

SDS

Target: SAA1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: SAA15

Application*: WB, SE

Mouse Anti-SAA1 Recombinant Antibody (CBXS-5723) (CBMAB-S0587-CQ)

SDS

Target: SAA1

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: CBXS-5723

Application*: E, WB

Mouse Anti-SAA1 Recombinant Antibody (CBXS-5779) (CBMAB-S0638-CQ)

SDS

Target: SAA1

Host: Mouse

Antibody Isotype: IgG2, κ

Specificity: Human

Clone: CBXS-5779

Application*: WB, E, P, SE

Mouse Anti-SAA1 Recombinant Antibody (CBXS-3642) (CBMAB-S0922-CQ)

SDS

Target: SAA1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXS-3642

Application*: E, WB

Mouse Anti-SAA1 Recombinant Antibody (CBXS-4794) (CBMAB-S2020-CQ)

SDS

Target: SAA1

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: CBXS-4794

Application*: E, WB

Rabbit Anti-SAA1 Recombinant Antibody (CBXS-5457) (CBMAB-S2667-CQ)

SDS

Target: SAA1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Mouse

Clone: CBXS-5457

Application*: WB

Mouse Anti-SAA1 Recombinant Antibody (CBXS-6123) (CBMAB-S2967-CQ)

SDS

Target: SAA1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXS-6123

Application*: E, WB

Mouse Anti-SAA1 Recombinant Antibody (CBXS-0101) (CBMAB-S3100-CQ)

SDS

Target: SAA1

Host: Mouse

Specificity: Human

Clone: CBXS-0101

Application*: WB, IC, P, C, E

Mouse Anti-SAA1 Recombinant Antibody (CBXS-0106) (CBMAB-S3101-CQ)

SDS

Target: SAA1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXS-0106

Application*: C, P

Mouse Anti-SAA1 Recombinant Antibody (CBXS-0107) (CBMAB-S3102-CQ)

SDS

Target: SAA1

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBXS-0107

Application*: E, WB, P

Rat Anti-SAA1 Recombinant Antibody (CBXS-1800) (CBMAB-S4613-CQ)

SDS

Target: SAA1

Host: Rat

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXS-1800

Application*: WB

Mouse Anti-SAA1 Recombinant Antibody (CBXS-1970) (CBMAB-S4743-CQ)

SDS

Target: SAA1

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBXS-1970

Application*: WB

Mouse Anti-SAA1 Recombinant Antibody (CBXS-1971) (CBMAB-S4744-CQ)

SDS

Target: SAA1

Host: Mouse

Antibody Isotype: IgG3

Specificity: Human

Clone: CBXS-1971

Application*: IH

Mouse Anti-SAA1 Recombinant Antibody (mc1) (CBMAB-S6420-CQ)

SDS

Target: SAA1

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: mc1

Application*: IH, P, C

Mouse Anti-SAA1 Recombinant Antibody (mcl) (CBMAB-S6424-CQ)

SDS

Target: SAA1

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: mcl

Application*: P

Mouse Anti-SAA1 Recombinant Antibody (Reu86.1) (CBMAB-S6495-CQ)

SDS

Target: SAA1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse

Clone: Reu86.1

Application*: E, C, P, WB

Mouse Anti-SAA1 Recombinant Antibody (Reu86.2) (CBMAB-S6496-CQ)

SDS

Target: SAA1

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: Reu86.2

Application*: E, IH

Mouse Anti-SAA1 Recombinant Antibody (Reu86.5) (CBMAB-S6497-CQ)

SDS

Target: SAA1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: Reu86.5

Application*: E, C, P, WB

Mouse Anti-SAA1 Recombinant Antibody (S3-F11) (CBMAB-S6526-CQ)

SDS

Target: SAA1

Host: Mouse

Antibody Isotype: IgM

Specificity: Human

Clone: S3-F11

Application*: E, WB

Mouse Anti-SAA1 Recombinant Antibody (1F2E1) (CBMAB-R4294-CN)

SDS

Target: SAA1

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 1F2E1

Application*: E

Recombinant Mouse Anti-SAA1 Antibody (CBHb184) (CBMAB-Hb956-LY)

SDS

Target: SAA1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse

Clone: CBHb184

Application*: IHC-F, Immuno assays, IHC-P, WB

Recombinant Mouse Anti-SAA1 Antibody (CBHb185) (CBMAB-Hb957-LY)

SDS

Target: SAA1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse

Clone: CBHb185

Application*: IHC-F, Immuno assays, IHC-P, WB

Mouse Anti-SAA1 Recombinant Antibody (CB321A) (CBMAB-CA321LY)

SDS

Target: SAA1

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CB321A

Application*: ELISA

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)

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