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Mouse Anti-SAA1 Recombinant Antibody (CBT3989) (V2LY-0625-LY1454)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBT3989
Antibody Isotype
IgG1
Application
IHC, FC

Basic Information

Immunogen
Purified recombinant fragment of human SAA1 (AA: 19-212) expressed in E. Coli.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:500-1:2,000
IHC-P1:200-1:1,000
FC1:200-1:400
ELISA1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
Sodium azide
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Serum Amyloid A1
Entrez Gene ID
6288
Function
Major acute phase protein.
Biological Process
Biological Process acute-phase responseIEA:UniProtKB-KW
Biological Process lymphocyte chemotaxisManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process macrophage chemotaxisManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of inflammatory response1 PublicationNAS:UniProtKB
Biological Process neutrophil chemotaxis1 PublicationNAS:UniProtKB
Biological Process platelet activation1 PublicationNAS:UniProtKB
Biological Process positive regulation of cell adhesionManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of cytokine productionManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of cytosolic calcium ion concentrationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of interleukin-1 production1 PublicationNAS:UniProtKB
Biological Process regulation of protein secretion1 PublicationNAS:UniProtKB
Cellular Location
Secreted
Involvement in disease
Reactive, secondary amyloidosis is characterized by the extracellular accumulation in various tissues of the SAA1 protein. These deposits are highly insoluble and resistant to proteolysis; they disrupt tissue structure and compromise function.
Elevated serum SAA1 protein levels may be associated with lung cancer.
PTM
This protein is the precursor of amyloid protein A, which is formed by the removal of approximately 24 residues from the C-terminal end.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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