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Mouse Anti-SERPINA7 Recombinant Antibody (CBYJT-1666) (CBMAB-T0715-YJ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-1666
Antibody Isotype
IgG1
Application
WB

Basic Information

Immunogen
Recombinant fragment corresponding to Human Thyroxine Binding Globulin aa 168-302. Expressed in E. coli. Sequence: AAKQEINSHVEMQTKGKVVGLIQDLKPNTIMVLVNYIHFKAQWANPFDPS KTEDSSSFLIDKTTTVQVPMMHQMEQYYHLVDMELNCTVLQMDYSKNALA LFVLPKEGQMESVEAAMSSKTLKKWNRLLQKGWVD
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 168-302

Target

Full Name
Serpin Family A Member 7
Introduction
There are three proteins including thyroxine-binding globulin (TBG), transthyretin and albumin responsible for carrying the thyroid hormones thyroxine (T4) and 3, 5, 3'-triiodothyronine (T3) in the bloodstream. SERPINA7 is the major thyroid hormone transport protein, TBG, in serum. It belongs to the serpin family in genomics, but the protein has no inhibitory function like many other members of the serpin family. Mutations in SERPINA7 result in TGB deficiency, which has been classified as partial deficiency, complete deficiency, and excess, based on the level of serum TBG.
Entrez Gene ID
6906
UniProt ID
P05543
Alternative Names
Serpin Family A Member 7; Serine (Or Cysteine) Proteinase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 7; Serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 7; Thyroxine-Binding Globulin; Thyroxin-Binding Globulin; T4-Binding Globulin
Function
Major thyroid hormone transport protein in serum.
Biological Process
Biological Process negative regulation of endopeptidase activityManual Assertion Based On ExperimentIBA:GO_Central
Biological Process thyroid hormone transportManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Secreted
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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