Mouse Anti-SPIRE1 Recombinant Antibody (4C5) (CBMAB-A8542-LY)
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Basic Information
Formulations & Storage [For reference only, actual COA shall prevail!]
Target
Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport (PubMed:11747823).
Required for asymmetric spindle positioning and asymmetric cell division during meiosis (PubMed:21620703).
Required for normal formation of the cleavage furrow and for polar body extrusion during female germ cell meiosis (PubMed:21620703).
Also acts in the nucleus: together with FMN2, promotes assembly of nuclear actin filaments in response to DNA damage in order to facilitate movement of chromatin and repair factors after DNA damage (PubMed:26287480).
In addition, promotes innate immune signaling downstream of dsRNA sensing (PubMed:35148361).
Mechanistically, contributes to IRF3 phosphorylation and activation downstream of MAVS and upstream of TBK1 (PubMed:35148361).
Biological Process actin filament network formationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process actin filament polymerizationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process actin nucleationIEA:InterPro
Biological Process cleavage furrow formationISS:UniProtKB
Biological Process establishment of meiotic spindle localizationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process formin-nucleated actin cable assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process Golgi vesicle transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process intracellular transportISS:UniProtKB
Biological Process polar body extrusion after meiotic divisionsISS:UniProtKB
Biological Process positive regulation of double-strand break repairManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of mitochondrial fissionManual Assertion Based On ExperimentIMP:CACAO
Biological Process protein transportIEA:UniProtKB-KW
Biological Process vesicle-mediated transportISS:UniProtKB
Cytoplasm, perinuclear region
Cell membrane
Cytoplasmic vesicle membrane
Detected at the cleavage furrow during asymmetric oocyte division and polar body extrusion (By similarity).
Punctate spots in perinuclear region and cytoplasm, colocalized with Rab11 (By similarity).
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Please try the standard protocols which include: protocols, troubleshooting and guide.
Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols
Custom Antibody Labeling
We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).
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