SPIRE1

Spire proteins, such as SPIRE1, are highly conserved between species. They belong to the family of Wiskott-Aldrich homology region-2 (WH2) proteins, which are involved in actin organization (Kerkhoff et al., 2001 [PubMed 11747823]).[supplied by OMIM

Full Name

spire homolog 1 (Drosophila)

Function

Acts as an actin nucleation factor, remains associated with the slow-growing pointed end of the new filament (PubMed:11747823, PubMed:21620703).
Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport (PubMed:11747823).
Required for asymmetric spindle positioning and asymmetric cell division during meiosis (PubMed:21620703).
Required for normal formation of the cleavage furrow and for polar body extrusion during female germ cell meiosis (PubMed:21620703).
Also acts in the nucleus: together with FMN2, promotes assembly of nuclear actin filaments in response to DNA damage in order to facilitate movement of chromatin and repair factors after DNA damage (PubMed:26287480).
In addition, promotes innate immune signaling downstream of dsRNA sensing (PubMed:35148361).
Mechanistically, contributes to IRF3 phosphorylation and activation downstream of MAVS and upstream of TBK1 (PubMed:35148361).

Biological Process

Biological Process actin cytoskeleton organizationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process actin filament network formationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process actin filament polymerizationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process actin nucleationIEA:InterPro
Biological Process cleavage furrow formationISS:UniProtKB
Biological Process establishment of meiotic spindle localizationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process formin-nucleated actin cable assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process Golgi vesicle transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process intracellular transportISS:UniProtKB
Biological Process polar body extrusion after meiotic divisionsISS:UniProtKB
Biological Process positive regulation of double-strand break repairManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of mitochondrial fissionManual Assertion Based On ExperimentIMP:CACAO
Biological Process protein transportIEA:UniProtKB-KW
Biological Process vesicle-mediated transportISS:UniProtKB

Cellular Location

Cytoplasm, cytoskeleton
Cytoplasm, perinuclear region
Cell membrane
Cytoplasmic vesicle membrane
Detected at the cleavage furrow during asymmetric oocyte division and polar body extrusion (By similarity).
Punctate spots in perinuclear region and cytoplasm, colocalized with Rab11 (By similarity).