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Mouse Anti-TACC3 Recombinant Antibody (CBYJT-1778) (CBMAB-T0839-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TACC3 (Transforming Acidic Coiled-Coil Containing Protein 3). The antibody can be used for immunoassay techniques, such as FC, ICC, IF, IHC, IHC-P, WB.
See all TACC3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-1778
Antibody Isotype
IgG1
Application
FC, ICC, IF, IHC, IHC-P, WB

Basic Information

Immunogen
Full length human recombinant protein of human TACC3(NP_006333) produced in HEK293T cell
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.3, 1% BSA, 50% Glycerol
Preservative
0.02% Sodium Azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
TACC3 Gene(Protein Coding) Transforming Acidic Coiled-Coil Containing Protein 3
Introduction
TACC3 is a member of the transforming acidic colied-coil protein family. TACC3 is a motor spindle protein that may function in stabilization of the mitotic spindle. TACC3 may also function in growth a differentiation of certain cancer cells.
Entrez Gene ID
10460
UniProt ID
Q9Y6A5
Alternative Names
Transforming Acidic Coiled-Coil Containing Protein 3; ERIC-1; ERIC1; Transforming, Acidic Coiled-Coil Containing Protein 3; Transforming Acidic Coiled-Coil-Containing Protein 3
Function
Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity).
Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:21297582, PubMed:23532825).
May be involved in the control of cell growth and differentiation. May contribute to cancer (PubMed:14767476).
Biological Process
Cell divisionIEA:UniProtKB-KW
Cell population proliferationManual Assertion Based On ExperimentIBA:GO_Central
Cerebral cortex developmentManual Assertion Based On ExperimentIBA:GO_Central
Metaphase/anaphase transition of mitotic cell cycleManual Assertion Based On ExperimentIMP:UniProtKB
Microtubule cytoskeleton organizationManual Assertion Based On ExperimentIBA:GO_Central
Microtubule cytoskeleton organization involved in mitosisManual Assertion Based On ExperimentIMP:UniProtKB
Mitotic spindle organizationIEA:InterPro
Regulation of mitotic spindle organizationManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Cytoplasm
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Cytoplasm, cytoskeleton, spindle
Cytoplasm, cytoskeleton, spindle pole
In complex with CKAP5 localized to microtubule plus-ends in mitosis and interphase. In complex with CKAP5 and clathrin localized to inter-microtubule bridges in mitotic spindles.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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