TACC3
This gene encodes a member of the transforming acidic colied-coil protein family. The encoded protein is a motor spindle protein that may play a role in stabilization of the mitotic spindle. This protein may also play a role in growth a differentiation of certain cancer cells. [provided by RefSeq, Nov 2011]
Full Name
TACC3 Gene(Protein Coding) Transforming Acidic Coiled-Coil Containing Protein 3
Function
Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity).
Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:21297582, PubMed:23532825).
May be involved in the control of cell growth and differentiation. May contribute to cancer (PubMed:14767476).
Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:21297582, PubMed:23532825).
May be involved in the control of cell growth and differentiation. May contribute to cancer (PubMed:14767476).
Biological Process
Cell divisionIEA:UniProtKB-KW
Cell population proliferationManual Assertion Based On ExperimentIBA:GO_Central
Cerebral cortex developmentManual Assertion Based On ExperimentIBA:GO_Central
Metaphase/anaphase transition of mitotic cell cycleManual Assertion Based On ExperimentIMP:UniProtKB
Microtubule cytoskeleton organizationManual Assertion Based On ExperimentIBA:GO_Central
Microtubule cytoskeleton organization involved in mitosisManual Assertion Based On ExperimentIMP:UniProtKB
Mitotic spindle organizationIEA:InterPro
Regulation of mitotic spindle organizationManual Assertion Based On ExperimentIMP:UniProtKB
Cell population proliferationManual Assertion Based On ExperimentIBA:GO_Central
Cerebral cortex developmentManual Assertion Based On ExperimentIBA:GO_Central
Metaphase/anaphase transition of mitotic cell cycleManual Assertion Based On ExperimentIMP:UniProtKB
Microtubule cytoskeleton organizationManual Assertion Based On ExperimentIBA:GO_Central
Microtubule cytoskeleton organization involved in mitosisManual Assertion Based On ExperimentIMP:UniProtKB
Mitotic spindle organizationIEA:InterPro
Regulation of mitotic spindle organizationManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Cytoplasm
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Cytoplasm, cytoskeleton, spindle
Cytoplasm, cytoskeleton, spindle pole
In complex with CKAP5 localized to microtubule plus-ends in mitosis and interphase. In complex with CKAP5 and clathrin localized to inter-microtubule bridges in mitotic spindles.
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Cytoplasm, cytoskeleton, spindle
Cytoplasm, cytoskeleton, spindle pole
In complex with CKAP5 localized to microtubule plus-ends in mitosis and interphase. In complex with CKAP5 and clathrin localized to inter-microtubule bridges in mitotic spindles.
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Anti-TACC3 antibodies
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CompareTarget: TACC3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Dog
Clone: CBYJT-1786
Application*: WB, IP, IF
Target: TACC3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Rat, Mouse
Clone: CBYJT-1785
Application*: WB, P, IC, IF
Target: TACC3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat
Clone: CBYJT-1784
Application*: F, IC, IF, WB
Target: TACC3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Monkey
Clone: CBYJT-1783
Application*: IF, WB
Target: TACC3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Monkey
Clone: 6F1
Application*: F, IC, IF, IH, P, WB
Target: TACC3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Monkey
Clone: CBYJT-1782
Application*: IC, IF, IH, P, WB
Target: TACC3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-1781
Application*: F, IC, IF, IH, P, WB
Target: TACC3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-1780
Application*: F, IC, IF, IH, P, WB
Target: TACC3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-1779
Application*: WB, IH, IF, F
Target: TACC3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-1778
Application*: F, IC, IF, IH, P, WB
Target: TACC3
Host: Mouse
Antibody Isotype: IgG3
Specificity: Human
Clone: CBFYE-1664
Application*: E, P, WB
Target: TACC3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYE-1663
Application*: F, IF, P, WB
Target: TACC3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 10G7
Application*: E, WB, IH
Target: TACC3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Dog
Clone: D9E4
Application*: WB, IP, IF (IC)
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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