TACC3

This gene encodes a member of the transforming acidic colied-coil protein family. The encoded protein is a motor spindle protein that may play a role in stabilization of the mitotic spindle. This protein may also play a role in growth a differentiation of certain cancer cells. [provided by RefSeq, Nov 2011]

TACC3 Gene(Protein Coding) Transforming Acidic Coiled-Coil Containing Protein 3

Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity).
Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:21297582, PubMed:23532825).
May be involved in the control of cell growth and differentiation. May contribute to cancer (PubMed:14767476).

Cell divisionIEA:UniProtKB-KW
Cell population proliferationManual Assertion Based On ExperimentIBA:GO_Central
Cerebral cortex developmentManual Assertion Based On ExperimentIBA:GO_Central
Metaphase/anaphase transition of mitotic cell cycleManual Assertion Based On ExperimentIMP:UniProtKB
Microtubule cytoskeleton organizationManual Assertion Based On ExperimentIBA:GO_Central
Microtubule cytoskeleton organization involved in mitosisManual Assertion Based On ExperimentIMP:UniProtKB
Mitotic spindle organizationIEA:InterPro
Regulation of mitotic spindle organizationManual Assertion Based On ExperimentIMP:UniProtKB

Cytoplasm
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Cytoplasm, cytoskeleton, spindle
Cytoplasm, cytoskeleton, spindle pole
In complex with CKAP5 localized to microtubule plus-ends in mitosis and interphase. In complex with CKAP5 and clathrin localized to inter-microtubule bridges in mitotic spindles.