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Mouse Anti-TBL1XR1 Recombinant Antibody (4E2) (CBMAB-A8901-LY)

The product is antibody recognizes TBL1XR1. The antibody 4E2 immunoassay techniques such as: WB, ELISA.
See all TBL1XR1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
4E2
Antibody Isotype
IgG1, κ
Application
WB, ELISA

Basic Information

Immunogen
TBL1XR1 (NP_071347, 81 a.a. ~ 178 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
TBL1XR1 Gene(Protein Coding) Transducin Beta Like 1 X-Linked Receptor 1
Introduction
The protein encoded by this gene has sequence similarity with members of the WD40 repeat-containing protein family. The WD40 group is a large family of proteins, which appear to have a regulatory function. It is believed that the WD40 repeats mediate protein-protein interactions and members of the family are involved in signal transduction, RNA processing, gene regulation, vesicular trafficking, cytoskeletal assembly and may play a role in the control of cytotypic differentiation. [provided by RefSeq]
Entrez Gene ID
79718
UniProt ID
Q9BZK7
Alternative Names
C21; DC42; FLJ12894; IRA1; TBLR1
Function
F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of the N-Cor corepressor complex that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of N-Cor complex, thereby allowing cofactor exchange, and transcription activation.
Biological Process
Biological Process blastocyst hatchingIEA:Ensembl
Biological Process chromatin organizationIEA:UniProtKB-KW
Biological Process fat pad developmentIEA:Ensembl
Biological Process histone deacetylationIBA:GO_Central1 Publication
Biological Process lipid catabolic processIEA:Ensembl
Biological Process multicellular organism growthIEA:Ensembl
Biological Process negative regulation of transcription by RNA polymerase IIIDA:UniProtKB1 Publication
Biological Process positive regulation of canonical Wnt signaling pathwayIMP:UniProtKB1 Publication
Biological Process positive regulation of DNA-templated transcriptionIDA:UniProtKB1 Publication
Biological Process positive regulation of transcription by RNA polymerase IIIDA:UniProtKB1 Publication
Biological Process proteasome-mediated ubiquitin-dependent protein catabolic processISS:UniProtKB
Biological Process regulation of transcription by RNA polymerase IIIBA:GO_Central1 Publication
Biological Process regulation of triglyceride metabolic processIEA:Ensembl
Biological Process response to dietary excessIEA:Ensembl
Biological Process white fat cell differentiationIEA:Ensembl
Cellular Location
Nucleus
Involvement in disease
Pierpont syndrome (PRPTS):
An autosomal dominant syndrome characterized by multiple congenital anomalies, global developmental delay, learning disability, palmar and plantar fat pads, and distinctive facial characteristics, especially when smiling.
Intellectual developmental disorder, autosomal dominant 41 (MRD41):
A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRD41 patients manifest delayed psychomotor development, variable severity of intellectual disability, and delayed language. Non-specific dysmorphic features and autistic behavior is observed in some patients.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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