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Mouse Anti-TBL1XR1 Recombinant Antibody (CBYJT-2103) (CBMAB-T1202-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TBL1XR1 (Transducin Beta Like 1 X-Linked Receptor 1). The antibody can be used for immunoassay techniques, such as ELISA, WB, IHC, ICC.
See all TBL1XR1 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat, Cattle, Pig, Dog, Zebrafish
Clone
CBYJT-2103
Antibody Isotype
IgG1
Application
ELISA, WB, IHC, ICC

Basic Information

Immunogen
This antibody detects endogenous levels TBLR1 and does not cross-react with related proteins
Specificity
Human, Mouse, Rat, Cattle, Pig, Dog, Zebrafish
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
100 mM Tris-glycine, 150 mM NaCl, pH 7.4, 50% Glycerol
Preservative
0.2% Sodium Azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
TBL1XR1 Gene(Protein Coding) Transducin Beta Like 1 X-Linked Receptor 1
Introduction
TBL1XR1 is a member of the WD40 repeat-containing gene family and shares sequence similarity with transducin (beta)-like 1X-linked (TBL1X). TBL1XR1 is thought to be a component of both nuclear receptor corepressor (N-CoR) and histone deacetylase 3 (HDAC 3) complexes, and is required for transcriptional activation by a variety of transcription factors. Mutations in these gene have been associated with some autism spectrum disorders, and one finding suggests that haploinsufficiency of this gene may be a cause of intellectual disability with dysmorphism. Mutations in TBL1XR1 as well as recurrent translocations involving this gene have also been observed in some tumors.
Entrez Gene ID
Human79718
Mouse81004
Rat365755
Pig100522831
Cattle614346
Dog488176
UniProt ID
HumanQ9BZK7
MouseQ8BHJ5
RatD3ZNF4
PigF1SGD0
CattleF1MFJ6
DogA0A8C0SU26
Alternative Names
Transducin Beta Like 1 X-Linked Receptor 1; Nuclear Receptor Corepressor/HDAC3 Complex Subunit TBLR1; TBL1-Related Protein 1; TBLR1; IRA1; Nuclear Receptor Co-Repressor/HDAC3 Complex Subunit; F-Box-Like/WD Repeat-Containing Protein TBL1XR1
Function
F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of the N-Cor corepressor complex that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of N-Cor complex, thereby allowing cofactor exchange, and transcription activation.
Biological Process
Biological Process blastocyst hatchingIEA:Ensembl
Biological Process chromatin organizationIEA:UniProtKB-KW
Biological Process fat pad developmentIEA:Ensembl
Biological Process histone deacetylationIBA:GO_Central1 Publication
Biological Process lipid catabolic processIEA:Ensembl
Biological Process multicellular organism growthIEA:Ensembl
Biological Process negative regulation of transcription by RNA polymerase IIIDA:UniProtKB1 Publication
Biological Process positive regulation of canonical Wnt signaling pathwayIMP:UniProtKB1 Publication
Biological Process positive regulation of DNA-templated transcriptionIDA:UniProtKB1 Publication
Biological Process positive regulation of transcription by RNA polymerase IIIDA:UniProtKB1 Publication
Biological Process proteasome-mediated ubiquitin-dependent protein catabolic processISS:UniProtKB
Biological Process regulation of transcription by RNA polymerase IIIBA:GO_Central1 Publication
Biological Process regulation of triglyceride metabolic processIEA:Ensembl
Biological Process response to dietary excessIEA:Ensembl
Biological Process white fat cell differentiationIEA:Ensembl
Cellular Location
Nucleus
Involvement in disease
Pierpont syndrome (PRPTS):
An autosomal dominant syndrome characterized by multiple congenital anomalies, global developmental delay, learning disability, palmar and plantar fat pads, and distinctive facial characteristics, especially when smiling.
Intellectual developmental disorder, autosomal dominant 41 (MRD41):
A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRD41 patients manifest delayed psychomotor development, variable severity of intellectual disability, and delayed language. Non-specific dysmorphic features and autistic behavior is observed in some patients.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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