Mouse Anti-TBL1XR1 Recombinant Antibody (CBYJT-2100) (CBMAB-T1199-YJ)

Name: Mouse Anti-TBL1XR1 Recombinant Antibody (CBYJT-2100)
SKU: CBMAB-T1199-YJ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBYJT-2100

Application

ICC, IHC, WB

Immunogen

Purified recombinant human TBLR1 protein fragments expressed in E. coli

Specificity

Human, Mouse

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

100 mM Tris-glycine, 150 mM NaCl, pH 7.4, 50% Glycerol

Preservative

0.2% Sodium Azide

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

TBL1XR1 Gene(Protein Coding) Transducin Beta Like 1 X-Linked Receptor 1

Introduction

TBL1XR1 is a member of the WD40 repeat-containing gene family and shares sequence similarity with transducin (beta)-like 1X-linked (TBL1X). TBL1XR1 is thought to be a component of both nuclear receptor corepressor (N-CoR) and histone deacetylase 3 (HDAC 3) complexes, and is required for transcriptional activation by a variety of transcription factors. Mutations in these gene have been associated with some autism spectrum disorders, and one finding suggests that haploinsufficiency of this gene may be a cause of intellectual disability with dysmorphism. Mutations in TBL1XR1 as well as recurrent translocations involving this gene have also been observed in some tumors.

Entrez Gene ID

Human	79718
Mouse	81004

UniProt ID

Human	Q9BZK7
Mouse	Q8BHJ5

Alternative Names

Transducin Beta Like 1 X-Linked Receptor 1; Nuclear Receptor Corepressor/HDAC3 Complex Subunit TBLR1; TBL1-Related Protein 1; TBLR1; IRA1; Nuclear Receptor Co-Repressor/HDAC3 Complex Subunit; F-Box-Like/WD Repeat-Containing Protein TBL1XR1

Function

F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of the N-Cor corepressor complex that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of N-Cor complex, thereby allowing cofactor exchange, and transcription activation.

Biological Process

Biological Process blastocyst hatchingIEA:Ensembl
Biological Process chromatin organizationIEA:UniProtKB-KW
Biological Process fat pad developmentIEA:Ensembl
Biological Process histone deacetylationIBA:GO_Central1 Publication
Biological Process lipid catabolic processIEA:Ensembl
Biological Process multicellular organism growthIEA:Ensembl
Biological Process negative regulation of transcription by RNA polymerase IIIDA:UniProtKB1 Publication
Biological Process positive regulation of canonical Wnt signaling pathwayIMP:UniProtKB1 Publication
Biological Process positive regulation of DNA-templated transcriptionIDA:UniProtKB1 Publication
Biological Process positive regulation of transcription by RNA polymerase IIIDA:UniProtKB1 Publication
Biological Process proteasome-mediated ubiquitin-dependent protein catabolic processISS:UniProtKB
Biological Process regulation of transcription by RNA polymerase IIIBA:GO_Central1 Publication
Biological Process regulation of triglyceride metabolic processIEA:Ensembl
Biological Process response to dietary excessIEA:Ensembl
Biological Process white fat cell differentiationIEA:Ensembl

Cellular Location

Nucleus

Involvement in disease

Pierpont syndrome (PRPTS):
An autosomal dominant syndrome characterized by multiple congenital anomalies, global developmental delay, learning disability, palmar and plantar fat pads, and distinctive facial characteristics, especially when smiling.
Intellectual developmental disorder, autosomal dominant 41 (MRD41):
A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRD41 patients manifest delayed psychomotor development, variable severity of intellectual disability, and delayed language. Non-specific dysmorphic features and autistic behavior is observed in some patients.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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