Human Recombinant ACVR1 protein, His & hFc Tag (V2LY-0526-LY1913)

Name: Human Recombinant ACVR1 protein, His & hFc Tag
SKU: V2LY-0526-LY1913
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Human

Tag

His & hFc Tag

Protein Construction

This product is Human Recombinant ACVR1 protein, His & hFc Tag consist of Amino Acid: 1-124 and predicts a molecular mass of 39.6 kDa.

Molecule Mass

39.6 kDa

Sequence

Amino Acid: 1-124

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>95% as determined by SDS-PAGE

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile Tris, NaCl, Glutathione, EDTA, DTT, PMSF, Glycerol

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

activin A receptor, type I

Function

On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin. May be involved for left-right pattern formation during embryogenesis (By similarity).

Biological Process

Activin receptor signaling pathway
Acute inflammatory response
Angiogenesis
Atrial septum primum morphogenesis
Atrioventricular valve morphogenesis
BMP signaling pathway
BMP signaling pathway involved in heart development
Branching involved in blood vessel morphogenesis
Cardiac muscle cell fate commitment
Cellular response to BMP stimulus
Cellular response to growth factor stimulus
Determination of left/right symmetry
Dorsal/ventral pattern formation
Embryonic heart tube morphogenesis
Endocardial cushion cell fate commitment
Endocardial cushion fusion
Endocardial cushion morphogenesis
G1/S transition of mitotic cell cycle
Gastrulation with mouth forming second
Germ cell development
Heart development
In utero embryonic development
Mesoderm formation
Mitral valve morphogenesis
Negative regulation of activin receptor signaling pathway
Negative regulation of extrinsic apoptotic signaling pathway
Negative regulation of signal transduction
Neural crest cell migration
Pathway-restricted SMAD protein phosphorylation
Peptidyl-threonine phosphorylation
Pharyngeal system development
Positive regulation of bone mineralization
Positive regulation of cell migration
Positive regulation of determination of dorsal identity
Positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation
Positive regulation of osteoblast differentiation
Positive regulation of pathway-restricted SMAD protein phosphorylation
Positive regulation of peptidyl-tyrosine phosphorylation
Positive regulation of transcription, DNA-templated
Positive regulation of transcription by RNA polymerase II
Protein phosphorylation
Regulation of ossification
Smooth muscle cell differentiation
Transforming growth factor beta receptor signaling pathway
Ventricular septum morphogenesis

Cellular Location

Membrane

Involvement in disease

Fibrodysplasia ossificans progressiva (FOP): A rare autosomal dominant connective tissue disorder resulting in skeletal malformations and progressive extraskeletal ossification. Heterotopic ossification begins in childhood and can be induced by trauma or may occur without warning. Bone formation is episodic and progressive, leading to a debilitating ankylosis of all major joints of the axial and appendicular skeleton, rendering movement impossible.

Topology

Extracellular: 21-123 aa
Helical: 124-146 aa
Cytoplasmic: 147-509 aa

Katagiri, T., Tsukamoto, S., & Kuratani, M. (2021). Accumulated Knowledge of Activin Receptor-Like Kinase 2 (ALK2)/Activin A Receptor, Type 1 (ACVR1) as a Target for Human Disorders. Biomedicines, 9(7), 736.

Lin, J. B., Chen, J. F., Lai, F. C., Li, X., Xie, J. B., Tu, Y. R., & Kang, M. Q. (2020). Involvement of activin a receptor type 1 (ACVR1) in the pathogenesis of primary focal hyperhidrosis. Biochemical and biophysical research communications, 528(2), 299-304.

Aykul, S., Corpina, R. A., Goebel, E. J., Cunanan, C. J., Dimitriou, A., Kim, H. J., ... & Idone, V. (2020). Activin A forms a non-signaling complex with ACVR1 and type II Activin/BMP receptors via its finger 2 tip loop. Elife, 9, e54582.

Omi, M., Kaartinen, V., & Mishina, Y. (2019). Activin A receptor type 1–mediated BMP signaling regulates RANKL-induced osteoclastogenesis via canonical SMAD-signaling pathway. Journal of Biological Chemistry, 294(47), 17818-17836.

Valer, J. A., Sánchez-de-Diego, C., Pimenta-Lopes, C., Rosa, J. L., & Ventura, F. (2019). ACVR1 function in health and disease. Cells, 8(11), 1366.

Cheng, J., Cao, X., Hao, D., Ma, Y., Qi, X., Chaogetu, B., ... & Chen, H. (2019). The ACVR1 gene is significantly associated with growth traits in Chinese beef cattle. Livestock Science, 229, 210-215.

Wang, Y., Sun, J. C., Wang, H. B., Xu, X. M., Kong, Q. J., Wang, Y. J., ... & Shi, J. G. (2019). ACVR1‐knockout promotes osteogenic differentiation by activating the Wnt signaling pathway in mice. Journal of cellular biochemistry, 120(5), 8185-8194.

Haupt, J., Xu, M., & Shore, E. M. (2018). Variable signaling activity by FOP ACVR1 mutations. Bone, 109, 232-240.

Hildebrand, L., Stange, K., Deichsel, A., Gossen, M., & Seemann, P. (2017). The Fibrodysplasia Ossificans Progressiva (FOP) mutation p. R206H in ACVR1 confers an altered ligand response. Cellular signalling, 29, 23-30.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Canine Recombinant ACVR1 protein, hFc Tag (CAT#: V2LY-0526-LY1198)

Canine Recombinant ACVR1 protein, His Tag (CAT#: V2LY-0526-LY1199)

Cynomolgus Recombinant ACVR1 protein, hFc Tag (CAT#: V2LY-0526-LY1364)

Human Recombinant ACVR1 (G328E), Active protein, GST Tag (CAT#: V2LY-0526-LY1908)

Human Recombinant ACVR1 (G328V), Active protein, GST Tag (CAT#: V2LY-0526-LY1909)

Human Recombinant ACVR1 (G328W), Active protein, GST Tag (CAT#: V2LY-0526-LY1910)

Human Recombinant ACVR1 (G356D), Active protein, GST Tag (CAT#: V2LY-0526-LY1911)

Human Recombinant ACVR1, Active protein, GST Tag (CAT#: V2LY-0526-LY1912)

Human Recombinant ACVR1 protein, His Tag (CAT#: V2LY-0526-LY1914)

Human Recombinant ACVR1 (PF197_198L), Active protein, GST Tag (CAT#: V2LY-0526-LY1915)

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Human Recombinant ACVR1 (R258G), Active protein, GST Tag (CAT#: V2LY-0526-LY1920)

Human Recombinant ACVR1 (G356D), Active protein, GST Tag (CAT#: V2LY-0526-LY1911)

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Human Recombinant ACVR1 (Q207D), Active protein, GST Tag (CAT#: V2LY-0526-LY1916)

Canine Recombinant ACVR1 protein, hFc Tag (CAT#: V2LY-0526-LY1198)

Human Recombinant ACVR1, Active protein, GST Tag (CAT#: V2LY-0526-LY1912)

Human Recombinant ACVR1 (PF197_198L), Active protein, GST Tag (CAT#: V2LY-0526-LY1915)

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Isotype control

For research use only. Not intended for any clinical use.

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