Human Recombinant GPC2 protein, ECD, His Tag (V2LY-0526-LY4387)

Brégère, C., Fisch, U., Halbeisen, F. S., Schneider, C., Dittmar, T., Stricker, S., ... & Guzman, R. (2023). Doublecortin and Glypican-2 concentrations in the cerebrospinal fluid from infants are developmentally downregulated. Plos one, 18(2), e0279343.

Li, N., & Ho, M. (2022). Development of Glypican-2 Targeting Single-Domain Antibody CAR T Cells for Neuroblastoma. In Single-Domain Antibodies: Methods and Protocols (pp. 451-468). New York, NY: Springer US.

Heitzeneder, S., Bosse, K. R., Zhu, Z., Zhelev, D., Majzner, R. G., Radosevich, M. T., ... & Mackall, C. L. (2022). GPC2-CAR T cells tuned for low antigen density mediate potent activity against neuroblastoma without toxicity. Cancer Cell, 40(1), 53-69.

Tian, M., Cheuk, A. T., Wei, J. S., Abdelmaksoud, A., Chou, H. C., Milewski, D., ... & Khan, J. (2022). An optimized bicistronic chimeric antigen receptor against GPC2 or CD276 overcomes heterogeneous expression in neuroblastoma. The Journal of Clinical Investigation, 132(16).

Li, N., Torres, M. B., Spetz, M. R., Wang, R., Peng, L., Tian, M., ... & Ho, M. (2021). CAR T cells targeting tumor-associated exons of glypican 2 regress neuroblastoma in mice. Cell Reports Medicine, 2(6), 100297.

Li, N., Spetz, M. R., Li, D., & Ho, M. (2021). Advances in immunotherapeutic targets for childhood cancers: A focus on glypican-2 and B7-H3. Pharmacology & therapeutics, 223, 107892.

Raman, S., Buongervino, S. N., Lane, M. V., Zhelev, D. V., Zhu, Z., Cui, H., ... & Bosse, K. R. (2021). A GPC2 antibody-drug conjugate is efficacious against neuroblastoma and small-cell lung cancer via binding a conformational epitope. Cell Reports Medicine, 2(7), 100344.

Foster, J., Griffin, C., Stern, A., Brimley, C., Buongervino, S., Storm, P., ... & Bosse, K. (2021). IMMU-16. Targeting Glypican 2 (Gpc2) On Pediatric Malignant Brain Tumors With Mrna Car T Cells. Neuro-Oncology, 23(Suppl 1), i30.

Zhang, T., Liu, Y., Ren, X., Wang, Z., & Wang, H. (2020). Glypican 2 regulates cell proliferation and metastasis in thyroid cancer cells. Molecular & Cellular Toxicology, 16, 203-209.

Heitzeneder, S., Bosse, K. R., Zhu, Z., Majzner, R. G., Theruvath, J., Xu, P., ... & Mackall, C. L. (2020). Abstract A09: Glypican-2 targeted CAR T cells designed to effectively eradicate endogenous site density solid tumors in the absence of toxicity. Cancer Research, 80(14_Supplement), A09-A09.

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols