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MDM4 Matched Antibody Pair (728) (APMAB-728LY)

This antibody pair set can be used for detecting and quantifying protein level of human MDM4.
See all MDM4 antibodies

Specifications

ApplIcation
Sandwich ELISA
Specificity
Human
Capture Antibody
Rabbit anti-MDM4 polyclonal antibody, 100 ug
Detection Antibody
Anti-MDM4 Mouse polyclonal antibody, 20 ug
Dilutions
10 ng/ml-100 ng/ml
Format
Liquid
Storage
Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.
Introduction
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 6 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of this protein by CDC2 kinase reduces the DNA helicase activity and chromatin binding of the MCM complex. This gene is mapped to a region on the chromosome 8 head-to-head next to the PRKDC/DNA-PK, a DNA-activated protein kinase involved in the repair of DNA double-strand breaks. Alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008]
Alternative Names
Minichromosome Maintenance Complex Component 4; CDC21 Homolog; P1-CDC21; CDC21; MCM4 Minichromosome Maintenance Deficient 4 (S. Cerevisiae); Homolog Of S. Pombe Cell Devision Cycle 21; Minichromosome Maintenance Deficient 4;
Entrez Gene ID
4194
UniProt ID
P33991

Sanford, J. D., Yang, J., Han, J., Tollini, L. A., Jin, A., & Zhang, Y. (2021). MDMX is essential for the regulation of p53 protein levels in the absence of a functional MDM2 C-terminal tail. BMC Molecular and Cell Biology, 22, 1-9.

Wu, J., Lu, G., & Wang, X. (2021). MDM4 alternative splicing and implication in MDM4 targeted cancer therapies. American Journal of Cancer Research, 11(12), 5864.

Zhang, S., Lou, J., Li, Y., Zhou, F., Yan, Z., Lyu, X., & Zhao, Y. (2021). Recent progress and clinical development of inhibitors that block MDM4/p53 protein–protein interactions. Journal of Medicinal Chemistry, 64(15), 10621-10640.

Eskandari, M., Shi, Y., Liu, J., Albanese, J., Goel, S., Verma, A., & Wang, Y. (2021). The expression of MDM2, MDM4, p53 and p21 in myeloid neoplasms and the effect of MDM2/MDM4 dual inhibitor. Leukemia & Lymphoma, 62(1), 167-175.

Wohlberedt, K., Klusmann, I., Derevyanko, P. K., Henningsen, K., Choo, J. A. M. Y., Manzini, V., ... & Dobbelstein, M. (2020). Mdm4 supports DNA replication in a p53-independent fashion. Oncogene, 39(25), 4828-4843.

Liu, T., Zhang, H., Yi, S., Gu, L., & Zhou, M. (2019). Mutual regulation of MDM 4 and TOP 2A in cancer cell proliferation. Molecular oncology, 13(5), 1047-1058.

Haupt, S., Mejía-Hernández, J. O., Vijayakumaran, R., Keam, S. P., & Haupt, Y. (2019). The long and the short of it: the MDM4 tail so far. Journal of molecular cell biology, 11(3), 231-244.

Karki, A., Putra, J., Kim, S. S., Laquaglia, M. J., Perez‑Atayde, A. R., Sadri‑Vakili, G., & Vakili, K. (2019). MDM4 expression in fibrolamellar hepatocellular carcinoma. Oncology Reports, 42(4), 1487-1496.

Frosi, Y., Inoue, K., Ramlan, S. R., Lane, D. P., Watanabe, T., & Brown, C. J. (2019). Simultaneous measurement of p53: Mdm2 and p53: Mdm4 protein-protein interactions in whole cells using fluorescence labelled foci. Scientific Reports, 9(1), 17933.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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