MDM4 Matched Antibody Pair (728) (APMAB-728LY)

Name: MDM4 Matched Antibody Pair (728)
SKU: APMAB-728LY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet References Q & As Review & reward Protocols Associated Products

Specifications

ApplIcation

Sandwich ELISA

Specificity

Human

Capture Antibody

Rabbit anti-MDM4 polyclonal antibody, 100 ug

Detection Antibody

Anti-MDM4 Mouse polyclonal antibody, 20 ug

Dilutions

10 ng/ml-100 ng/ml

Format

Liquid

Storage

Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.

Introduction

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 6 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of this protein by CDC2 kinase reduces the DNA helicase activity and chromatin binding of the MCM complex. This gene is mapped to a region on the chromosome 8 head-to-head next to the PRKDC/DNA-PK, a DNA-activated protein kinase involved in the repair of DNA double-strand breaks. Alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008]

Alternative Names

Minichromosome Maintenance Complex Component 4; CDC21 Homolog; P1-CDC21; CDC21; MCM4 Minichromosome Maintenance Deficient 4 (S. Cerevisiae); Homolog Of S. Pombe Cell Devision Cycle 21; Minichromosome Maintenance Deficient 4;

Entrez Gene ID

4194

UniProt ID

P33991

More Infomation

Sanford, J. D., Yang, J., Han, J., Tollini, L. A., Jin, A., & Zhang, Y. (2021). MDMX is essential for the regulation of p53 protein levels in the absence of a functional MDM2 C-terminal tail. BMC Molecular and Cell Biology, 22, 1-9.

Wu, J., Lu, G., & Wang, X. (2021). MDM4 alternative splicing and implication in MDM4 targeted cancer therapies. American Journal of Cancer Research, 11(12), 5864.

Zhang, S., Lou, J., Li, Y., Zhou, F., Yan, Z., Lyu, X., & Zhao, Y. (2021). Recent progress and clinical development of inhibitors that block MDM4/p53 protein–protein interactions. Journal of Medicinal Chemistry, 64(15), 10621-10640.

Eskandari, M., Shi, Y., Liu, J., Albanese, J., Goel, S., Verma, A., & Wang, Y. (2021). The expression of MDM2, MDM4, p53 and p21 in myeloid neoplasms and the effect of MDM2/MDM4 dual inhibitor. Leukemia & Lymphoma, 62(1), 167-175.

Wohlberedt, K., Klusmann, I., Derevyanko, P. K., Henningsen, K., Choo, J. A. M. Y., Manzini, V., ... & Dobbelstein, M. (2020). Mdm4 supports DNA replication in a p53-independent fashion. Oncogene, 39(25), 4828-4843.

Liu, T., Zhang, H., Yi, S., Gu, L., & Zhou, M. (2019). Mutual regulation of MDM 4 and TOP 2A in cancer cell proliferation. Molecular oncology, 13(5), 1047-1058.

Haupt, S., Mejía-Hernández, J. O., Vijayakumaran, R., Keam, S. P., & Haupt, Y. (2019). The long and the short of it: the MDM4 tail so far. Journal of molecular cell biology, 11(3), 231-244.

Karki, A., Putra, J., Kim, S. S., Laquaglia, M. J., Perez‑Atayde, A. R., Sadri‑Vakili, G., & Vakili, K. (2019). MDM4 expression in fibrolamellar hepatocellular carcinoma. Oncology Reports, 42(4), 1487-1496.

Frosi, Y., Inoue, K., Ramlan, S. R., Lane, D. P., Watanabe, T., & Brown, C. J. (2019). Simultaneous measurement of p53: Mdm2 and p53: Mdm4 protein-protein interactions in whole cells using fluorescence labelled foci. Scientific Reports, 9(1), 17933.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

MDM4 Matched Antibody Pair (727) (CAT#: APMAB-727LY)

Antibody Pairs

MDM4 Matched Antibody Pair (727) (CAT#: APMAB-727LY)

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Isotype control

For research use only. Not intended for any clinical use.

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