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WNT1

The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is very conserved in evolution, and the protein encoded by this gene is known to be 98% identical to the mouse Wnt1 protein at the amino acid level. The studies in mouse indicate that the Wnt1 protein functions in the induction of the mesencephalon and cerebellum. This gene was originally considered as a candidate gene for Joubert syndrome, an autosomal recessive disorder with cerebellar hypoplasia as a leading feature. However, further studies suggested that the gene mutations might not have a significant role in Joubert syndrome. This gene is clustered with another family member, WNT10B, in the chromosome 12q13 region. [provided by RefSeq, Jul 2008]
Full Name
Wnt Family Member 1
Function
Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Acts in the canonical Wnt signaling pathway by promoting beta-catenin-dependent transcriptional activation (PubMed:23499309, PubMed:26902720, PubMed:28528193, PubMed:23656646).
In some developmental processes, is also a ligand for the coreceptor RYK, thus triggering Wnt signaling (By similarity).
Plays an essential role in the development of the embryonic brain and central nervous system (CNS) (By similarity).
Has a role in osteoblast function, bone development and bone homeostasis (PubMed:23499309, PubMed:23656646).
Biological Process
Biological Process animal organ regeneration Source:Ensembl
Biological Process astrocyte-dopaminergic neuron signaling Source:Ensembl
Biological Process bone development Source:UniProtKB1 Publication
Biological Process branching involved in ureteric bud morphogenesis Source:Ensembl
Biological Process canonical Wnt signaling pathway Source:BHF-UCL2 Publications
Biological Process canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation Source:ParkinsonsUK-UCL1 Publication
Biological Process cell fate commitment Source:GO_Central1 Publication
Biological Process cell proliferation in midbrain Source:Ensembl
Biological Process cell-cell signaling Source:BHF-UCL
Biological Process cellular response to peptide hormone stimulus Source:Ensembl
Biological Process central nervous system morphogenesis Source:BHF-UCL
Biological Process cerebellum formation Source:BHF-UCL
Biological Process diencephalon development Source:Ensembl
Biological Process embryonic axis specification Source:BHF-UCL
Biological Process embryonic brain development Source:Ensembl
Biological Process fat cell differentiation Source:Ensembl
Biological Process forebrain anterior/posterior pattern specification Source:Ensembl
Biological Process hematopoietic stem cell proliferation Source:Ensembl
Biological Process hepatocyte differentiation Source:Ensembl
Biological Process inner ear morphogenesis Source:Ensembl
Biological Process midbrain development Source:BHF-UCL
Biological Process midbrain-hindbrain boundary maturation during brain development Source:Ensembl
Biological Process myoblast fusion Source:Ensembl
Biological Process negative regulation of apoptotic process Source:BHF-UCL1 Publication
Biological Process negative regulation of BMP signaling pathway Source:AgBase1 Publication
Biological Process negative regulation of cell-cell adhesion Source:BHF-UCL1 Publication
Biological Process negative regulation of cell-substrate adhesion Source:BHF-UCL1 Publication
Biological Process negative regulation of cellular senescence Source:BHF-UCL1 Publication
Biological Process negative regulation of fat cell differentiation Source:BHF-UCL
Biological Process negative regulation of oxidative stress-induced neuron death Source:Ensembl
Biological Process negative regulation of transforming growth factor beta receptor signaling pathway Source:Ensembl
Biological Process negative regulation of ubiquitin-dependent protein catabolic process Source:Ensembl
Biological Process neuron differentiation Source:GO_Central1 Publication
Biological Process neuron fate determination Source:Ensembl
Biological Process positive regulation of cell population proliferation Source:BHF-UCL1 Publication
Biological Process positive regulation of dermatome development Source:BHF-UCL1 Publication
Biological Process positive regulation of DNA-binding transcription factor activity Source:BHF-UCL
Biological Process positive regulation of DNA-templated transcription Source:BHF-UCL1 Publication
Biological Process positive regulation of fibroblast proliferation Source:BHF-UCL1 Publication
Biological Process positive regulation of hematopoietic stem cell proliferation Source:Ensembl
Biological Process positive regulation of insulin-like growth factor receptor signaling pathway Source:BHF-UCL1 Publication
Biological Process positive regulation of lamellipodium assembly Source:BHF-UCL1 Publication
Biological Process positive regulation of Notch signaling pathway Source:BHF-UCL1 Publication
Biological Process positive regulation of protein phosphorylation Source:Ensembl
Biological Process positive regulation of transcription by RNA polymerase II Source:Ensembl
Biological Process response to wounding Source:UniProtKB1 Publication
Biological Process signal transduction in response to DNA damage Source:BHF-UCL1 Publication
Biological Process Spemann organizer formation Source:BHF-UCL
Biological Process spinal cord association neuron differentiation Source:Ensembl
Biological Process T cell differentiation in thymus Source:Ensembl
Biological Process ubiquitin-dependent SMAD protein catabolic process Source:Ensembl
Biological Process Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation Source:ParkinsonsUK-UCL1 Publication
Cellular Location
Secreted, extracellular space, extracellular matrix
Secreted
Involvement in disease
Osteoporosis (OSTEOP):
A systemic skeletal disorder characterized by decreased bone mass and deterioration of bone microarchitecture without alteration in the composition of bone. The result is fragile bones and an increased risk of fractures, even after minimal trauma. Osteoporosis is a chronic condition of multifactorial etiology and is usually clinically silent until a fracture occurs.
Osteogenesis imperfecta 15 (OI15):
An autosomal recessive form of osteogenesis imperfecta, a connective tissue disorder characterized by low bone mass, bone fragility and susceptibility to fractures after minimal trauma. Disease severity ranges from very mild forms without fractures to intrauterine fractures and perinatal lethality. Extraskeletal manifestations, which affect a variable number of patients, are dentinogenesis imperfecta, hearing loss, and blue sclerae. OI15 is characterized by early-onset recurrent fractures, bone deformity, significant reduction of bone density, short stature, and, in some patients, blue sclerae. Tooth development and hearing are normal. Learning and developmental delays and brain anomalies have been observed in some patients.
PTM
Palmitoleoylation is required for efficient binding to frizzled receptors. Palmitoleoylation is necessary for proper trafficking to cell surface (Probable). Depalmitoleoylated by NOTUM, leading to inhibit Wnt signaling pathway (By similarity).

Anti-WNT1 antibodies

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Target: WNT1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: 10C8
Application*: E, WB, IH, IF, F
Target: WNT1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse
Clone: CBWJW-202
Application*: E, WB
Target: WNT1
Host: Mouse
Antibody Isotype: IgM, κ
Specificity: Human, Mouse, Rat
Clone: 20C3.1
Application*: WB
Target: WNT1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJW-052
Application*: F, IF, WB
Target: WNT1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: CBWJW-053
Application*: E, WB, P, IF
Target: WNT1
Host: Mouse
Specificity: Human, Mouse, Rat
Clone: CBWJW-054
Application*: WB, IP, IH, IC, F
Target: WNT1
Host: Mouse
Specificity: Mouse, Rat, Human
Clone: CBWJW-138
Application*: WB, IP, IF, E
Target: WNT1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: CBFYM-3183
Application*: E, WB
Target: WNT1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: 6G6-D4-A11
Application*: WB, IH, IC, F
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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