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ACLY

ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440,000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Dec 2014]
Full Name
ATP Citrate Lyase
Function
Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis.
Biological Process
Acetyl-CoA biosynthetic process
Cholesterol biosynthetic process
Citrate metabolic process
Coenzyme A metabolic process
Fatty acid biosynthetic process
Fatty-acyl-CoA biosynthetic process
Lipid biosynthetic process
Neutrophil degranulation
Oxaloacetate metabolic process
Positive regulation of cellular metabolic process
Cellular Location
Cytosol
PTM
Phosphorylated by PKA and GSK3 in a sequential manner; phosphorylation results in activation of its activity. Phosphorylation on Thr-447 and Ser-451 depends on the phosphorylation state of Ser-455 (By similarity). Phosphorylation on Ser-455 is decreased by prior phosphorylation on the other 2 residues (By similarity).
ISGylated.
Acetylated at Lys-540, Lys-546 and Lys-554 by KAT2B/PCAF. Acetylation is promoted by glucose and stabilizes the protein, probably by preventing ubiquitination at the same sites. Acetylation promotes de novo lipid synthesis. Deacetylated by SIRT2.
Ubiquitinated at Lys-540, Lys-546 and Lys-554 by UBR4, leading to its degradation. Ubiquitination is probably inhibited by acetylation at same site (Probable).
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Anti-ACLY antibodies

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Mouse Anti-ACLY Recombinant Antibody (V2-179314) (CBMAB-A0610-YC)

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Target: ACLY
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Monkey, Rat
Clone: V2-179314
Application*: E, F, IC, IF, IH, P, WB
Datasheet SDS

Mouse Anti-ACLY Recombinant Antibody (V2-631896) (CBMAB-CA080LY)

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Target: ACLY
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Mouse, Rat, Pig
Clone: V2-631896
Application*: ELISA, WB, ICC, FC
Datasheet SDS

Mouse Anti-ACLY Recombinant Antibody (V2-630606) (CBMAB-BR003LY)

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Target: ACLY
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse, Rat
Clone: V2-630606
Application*: FC, IHC-P, WB
Datasheet SDS

Rabbit Anti-ACLY Recombinant Antibody (V2-179319) (CBMAB-A0615-YC)

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Target: ACLY
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: V2-179319
Application*: IC, IF
Datasheet SDS

Mouse Anti-ACLY Recombinant Antibody (V2-179313) (CBMAB-A0609-YC)

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Target: ACLY
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: V2-179313
Application*: IC, IF, IH, P, WB
Datasheet SDS

Mouse Anti-ACLY Recombinant Antibody (V2-179312) (CBMAB-A0608-YC)

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Target: ACLY
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: V2-179312
Application*: F, IC, IF, WB
Datasheet SDS

Mouse Anti-ACLY Recombinant Antibody (V2-179310) (CBMAB-A0606-YC)

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Target: ACLY
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Monkey, Mouse
Clone: V2-179310
Application*: F, IC, WB
Datasheet SDS

Mouse Anti-ACLY Recombinant Antibody (V2-179309) (CBMAB-A0605-YC)

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Target: ACLY
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Monkey, Mouse
Clone: V2-179309
Application*: E, F, IC, IH, WB
Datasheet SDS

Mouse Anti-ACLY Recombinant Antibody (CBT196) (V2LY-0625-LY3717)

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Target: ACLY
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Cattle, Chicken, Pig, Sheep
Clone: CBT196
Application*: WB, IF, IC, F
Datasheet SDS

Mouse Anti-ACLY Recombinant Antibody (CBT3317) (V2LY-0625-LY2791)

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Target: ACLY
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Monkey, Rat
Clone: CBT3317
Application*: WB, IH, IC, F
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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