ACLY
ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440,000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Dec 2014]
Full Name
ATP Citrate Lyase
Function
Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis.
Biological Process
Acetyl-CoA biosynthetic process
Cholesterol biosynthetic process
Citrate metabolic process
Coenzyme A metabolic process
Fatty acid biosynthetic process
Fatty-acyl-CoA biosynthetic process
Lipid biosynthetic process
Neutrophil degranulation
Oxaloacetate metabolic process
Positive regulation of cellular metabolic process
Cholesterol biosynthetic process
Citrate metabolic process
Coenzyme A metabolic process
Fatty acid biosynthetic process
Fatty-acyl-CoA biosynthetic process
Lipid biosynthetic process
Neutrophil degranulation
Oxaloacetate metabolic process
Positive regulation of cellular metabolic process
Cellular Location
Cytosol
PTM
Phosphorylated by PKA and GSK3 in a sequential manner; phosphorylation results in activation of its activity. Phosphorylation on Thr-447 and Ser-451 depends on the phosphorylation state of Ser-455 (By similarity). Phosphorylation on Ser-455 is decreased by prior phosphorylation on the other 2 residues (By similarity).
ISGylated.
Acetylated at Lys-540, Lys-546 and Lys-554 by KAT2B/PCAF. Acetylation is promoted by glucose and stabilizes the protein, probably by preventing ubiquitination at the same sites. Acetylation promotes de novo lipid synthesis. Deacetylated by SIRT2.
Ubiquitinated at Lys-540, Lys-546 and Lys-554 by UBR4, leading to its degradation. Ubiquitination is probably inhibited by acetylation at same site (Probable).
ISGylated.
Acetylated at Lys-540, Lys-546 and Lys-554 by KAT2B/PCAF. Acetylation is promoted by glucose and stabilizes the protein, probably by preventing ubiquitination at the same sites. Acetylation promotes de novo lipid synthesis. Deacetylated by SIRT2.
Ubiquitinated at Lys-540, Lys-546 and Lys-554 by UBR4, leading to its degradation. Ubiquitination is probably inhibited by acetylation at same site (Probable).
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Anti-ACLY antibodies
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CompareTarget: ACLY
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Monkey, Rat
Clone: V2-179314
Application*: E, F, IC, IF, IH, P, WB
Target: ACLY
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Mouse, Rat, Pig
Clone: V2-631896
Application*: ELISA, WB, ICC, FC
Target: ACLY
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse, Rat
Clone: V2-630606
Application*: FC, IHC-P, WB
Target: ACLY
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: V2-179319
Application*: IC, IF
Target: ACLY
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: V2-179313
Application*: IC, IF, IH, P, WB
Target: ACLY
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: V2-179312
Application*: F, IC, IF, WB
Target: ACLY
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Monkey, Mouse
Clone: V2-179310
Application*: F, IC, WB
Target: ACLY
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Monkey, Mouse
Clone: V2-179309
Application*: E, F, IC, IH, WB
Target: ACLY
Sensitivity: 0.0097 ng/mL
Detection Range: 0.02-6 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Target: ACLY
Expressed Host: Baculovirus-Insect Cells
Sequence: Amino Acid: 1-1101
Tag: His Tag
Target: ACLY
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 3A5
Application*: E, WB, IF, F
Target: ACLY
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Mouse, Rat, Pig
Clone: 11H7
Application*: E, WB, IC, F
Target: ACLY
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Cattle, Chicken, Pig, Sheep
Clone: CBT196
Application*: WB, IF, IC, F
Target: ACLY
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Monkey, Rat
Clone: CBT3317
Application*: WB, IH, IC, F
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(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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