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ARNT

This gene encodes a protein containing a basic helix-loop-helix domain and two characteristic PAS domains along with a PAC domain. The encoded protein binds to ligand-bound aryl hydrocarbon receptor and aids in the movement of this complex to the nucleus, where it promotes the expression of genes involved in xenobiotic metabolism. This protein is also a co-factor for transcriptional regulation by hypoxia-inducible factor 1. Chromosomal translocation of this locus with the ETV6 (ets variant 6) gene on chromosome 12 have been described in leukemias. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2013]
Full Name
Aryl Hydrocarbon Receptor Nuclear Translocator
Function
Required for activity of the Ah (dioxin) receptor. This protein is required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex then initiates transcription of genes involved in the activation of PAH procarcinogens. The heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters and functions as a transcriptional regulator of the adaptive response to hypoxia (By similarity).
The heterodimer ARNT:AHR binds to core DNA sequence 5'-TGCGTG-3' within the dioxin response element (DRE) of target gene promoters and activates their transcription (PubMed:28396409).
Biological Process
Cell differentiation Source: Ensembl
Embryonic placenta development Source: Ensembl
Positive regulation of endothelial cell proliferation Source: BHF-UCL
Positive regulation of erythrocyte differentiation Source: BHF-UCL
Positive regulation of glycolytic process Source: BHF-UCL
Positive regulation of hormone biosynthetic process Source: BHF-UCL
Positive regulation of protein sumoylation Source: Ensembl
Positive regulation of transcription by RNA polymerase II Source: BHF-UCL
Positive regulation of vascular endothelial growth factor production Source: BHF-UCL
Positive regulation of vascular endothelial growth factor receptor signaling pathway Source: BHF-UCL
Regulation of transcription by RNA polymerase II Source: GO_Central
Regulation of transcription from RNA polymerase II promoter in response to hypoxia Source: Reactome
Regulation of transcription from RNA polymerase II promoter in response to oxidative stress Source: BHF-UCL
Response to hypoxia Source: BHF-UCL
Xenobiotic metabolic process Source: Reactome
Cellular Location
Nucleus

Anti-ARNT antibodies

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Target: ARNT
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: CBFYH-2918
Application*: WB, IP, IF, E
Target: ARNT
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: CBFYH-2917
Application*: WB, IP, IF, P
Target: ARNT
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Monkey
Clone: D28F3
Application*: WB, IP, P
Target: ARNT
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse, Rat
Clone: CAP178
Application*: WB, IP, IF, E
Target: ARNT
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYC-A789
Application*: WB, IP, IF, E
Target: ARNT
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat, Cattle
Clone: H1beta234
Application*: WB, IH, IC, IF, P
Target: ARNT
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat, Zebrafish
Clone: 2B10
Application*: WB, IH, IC, IF, IP, P
Target: ARNT
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 1F12
Application*: E, WB
Target: ARNT
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1D10
Application*: IF, IH, WB
Target: ARNT
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3D10
Application*: IH, IF, WB
Target: ARNT
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: 1A1
Application*: FC, IF, IH, WB
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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