CACNA1I

Voltage-dependent calcium channels control the rapid entry of Ca(2+) into a variety of cell types and are therefore involved in both electrical and cellular signaling. T-type channels, such as CACNA1I, are activated by small membrane depolarizations and can generate burst firing and pacemaker activity.[supplied by OMIM

calcium channel, voltage-dependent, T type, alpha 1I subunit

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the 'low-voltage activated (LVA)' group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite negative potentials, and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes. Gates in voltage ranges similar to, but higher than alpha 1G or alpha 1H (By similarity).

Calcium ion import Source: GO_Central
Flagellated sperm motility Source: InterPro
Membrane depolarization during action potential Source: GO_Central
Neuronal action potential Source: GO_Central
Positive regulation of calcium ion-dependent exocytosis Source: GO_Central
Regulation of ion transmembrane transport Source: UniProtKB-KW
Signal transduction Source: ProtInc
Sleep Source: Ensembl

Membrane

Cytoplasmic: 1-78 aa
Helical: 79-99 aa
Extracellular: 100-120 aa
Helical: 121-141 aa
Cytoplasmic: 142-148 aa
Helical: 149-168 aa
Extracellular: 169-173 aa
Helical: 174-191 aa
Cytoplasmic: 192-211 aa
Helical: 212-232 aa
Extracellular: 233-377 aa
Helical: 378-398 aa
Cytoplasmic: 399-640 aa
Helical: 641-661 aa
Extracellular: 662-676 aa
Helical: 677-697 aa
Cytoplasmic: 698-702 aa
Helical: 703-721 aa
Extracellular: 722-729 aa
Helical: 730-753 aa
Cytoplasmic: 754-764 aa
Helical: 765-785 aa
Extracellular: 786-841 aa
Helical: 842-862 aa
Cytoplasmic: 863-1166 aa
Helical: 1167-1187 aa
Extracellular: 1188-1209 aa
Helical: 1210-1230 aa
Cytoplasmic: 1231-1244 aa
Helical: 1245-1265 aa
Extracellular: 1266-1272 aa
Helical: 1273-1294 aa
Cytoplasmic: 1295-1304 aa
Helical: 1305-1325 aa
Extracellular: 1326-1410 aa
Helical: 1411-1431 aa
Cytoplasmic: 1432-1485 aa
Helical: 1486-1506 aa
Extracellular: 1507-1522 aa
Helical: 1523-1543 aa
Cytoplasmic: 1544-1556 aa
Helical: 1557-1577 aa
Extracellular: 1578-1583 aa
Helical: 1584-1607 aa
Cytoplasmic: 1608-1621 aa
Helical: 1622-1642 aa
Extracellular: 1643-1709 aa
Helical: 1710-1730 aa
Cytoplasmic: 1731-2223 aa

In response to raising of intracellular calcium, the T-type channels are activated by CaM-kinase II.