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CANX

This gene encodes a member of the calnexin family of molecular chaperones. The encoded protein is a calcium-binding, endoplasmic reticulum (ER)-associated protein that interacts transiently with newly synthesized N-linked glycoproteins, facilitating protein folding and assembly. It may also play a central role in the quality control of protein folding by retaining incorrectly folded protein subunits within the ER for degradation. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]

Full Name

Calnexin

Function

Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor-mediated endocytosis at the synapse.

Biological Process

Antigen processing and presentation of exogenous peptide antigen via MHC class II Source: Reactome
Antigen processing and presentation of peptide antigen via MHC class I Source: Reactome
Clathrin-dependent endocytosis Source: UniProtKB
Endoplasmic reticulum unfolded protein response Source: GO_Central
Interleukin-27-mediated signaling pathway Source: Reactome
Interleukin-35-mediated signaling pathway Source: Reactome
Protein folding Source: GO_Central
Protein folding in endoplasmic reticulum Source: ParkinsonsUK-UCL
Protein secretion Source: ProtInc
Synaptic vesicle endocytosis Source: UniProtKB
Viral protein processing Source: Reactome

Cellular Location

Endoplasmic reticulum membrane; Endoplasmic reticulum; Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:12643545, PubMed:17081065). The palmitoylated form preferentially localizes to the perinuclear rough ER (PubMed:22314232).

Topology

Lumenal: 21-481 aa
Helical: 482-502 aa
Cytoplasmic: 503-592 aa

PTM

Phosphorylated at Ser-564 by MAPK3/ERK1. phosphorylation by MAPK3/ERK1 increases its association with ribosomes (By similarity).
Palmitoylation by DHHC6 leads to the preferential localization to the perinuclear rough ER. It mediates the association of calnexin with the ribosome-translocon complex (RTC) which is required for efficient folding of glycosylated proteins.
Ubiquitinated, leading to proteasomal degradation. Probably ubiquitinated by ZNRF4.

Anti-CANX antibodies

Mouse Anti-CANX Recombinant Antibody (CBXC-1956) (CBMAB-C4766-CQ)

SDS

Target: CANX

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: CBXC-1956

Application*: E, WB, IH

Mouse Anti-CANX Recombinant Antibody (CBXC-0058) (CBMAB-C4765-CQ)

SDS

Target: CANX

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBXC-0058

Application*: E, IF, P, WB

Mouse Anti-CANX Recombinant Antibody (IE2.1C12) (CBMAB-C0731-CQ)

SDS

Target: CANX

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: IE2.1C12

Application*: WB, F, IH, IF, P, IS

Mouse Anti-CANX Recombinant Antibody (CANX/1541) (CBMAB-C0520-CQ)

SDS

Target: CANX

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: CANX/1541

Application*: WB, F, IF, P

Mouse Anti-CANX Recombinant Antibody (AF18) (CBMAB-C0392-CQ)

SDS

Target: CANX

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse, Rat, Monkey

Clone: AF18

Application*: WB, IH, IF, P

Mouse Anti-CANX Recombinant Antibody (CBXC-2492) (CBMAB-C0060-CQ)

SDS

Target: CANX

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: CBXC-2492

Application*: WB, IH, IF, P, IS

Mouse Anti-CANX Recombinant Antibody (CBFYC-0786) (CBMAB-C0841-FY)

SDS

Target: CANX

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse

Clone: CBFYC-0786

Application*: E, WB

Mouse Anti-CANX Recombinant Antibody (CBFYC-0785) (CBMAB-C0840-FY)

SDS

Target: CANX

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBFYC-0785

Application*: E, P, WB

Mouse Anti-CANX Recombinant Antibody (CBFYC-0784) (CBMAB-C0839-FY)

SDS

Target: CANX

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human, Mouse, Rat

Clone: CBFYC-0784

Application*: WB

Mouse Anti-CANX (AA 1-300) Recombinant Antibody (CBFYC-0380) (CBMAB-C0420-FY)

SDS

Target: CANX

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: CBFYC-0380

Application*: WB, IH, IF, P, F

Mouse Anti-CANX Recombinant Antibody (CAP299) (CBMAB-AP766LY)

SDS

Target: CANX

Host: Mouse

Antibody Isotype: IgG

Specificity: Human, Mouse, Pig

Clone: CAP299

Application*: WB

Mouse Anti-CANX Recombinant Antibody (C6) (CBMAB-AP765LY)

SDS

Target: CANX

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human, Mouse

Clone: C6

Application*: ICC, IHC, IP, WB

Mouse Anti-CANX Recombinant Antibody (CBLC081-LY) (CBMAB-C9682-LY)

SDS

Target: CANX

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBLC081-LY

Application*: IC, IF, IP, WB

Mouse Anti-CANX Recombinant Antibody (CBYY-C0928) (CBMAB-C2365-YY)

SDS

Target: CANX

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBYY-C0928

Application*: IP, P, IC, F, E

Mouse Anti-CANX Recombinant Antibody (CBYY-C0045) (CBMAB-C0129-YY)

SDS

Target: CANX

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Dog, Mouse, Rat

Clone: CBYY-C0045

Application*: WB, BI, IH, IP

Mouse Anti-CANX Recombinant Antibody (2Q270) (CBMAB-C5361-LY)

SDS

Target: CANX

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse

Clone: 2Q270

Application*: E, WB, IP, IH, IC

Mouse Anti-CANX Recombinant Antibody (1563) (CBMAB-C3219-LY)

SDS

Target: CANX

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human, Mouse, Rat

Clone: 1563

Application*: WB

Mouse Anti-CANX Recombinant Antibody (13B94) (CBMAB-C2852-LY)

SDS

Target: CANX

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 13B94

Application*: E, WB

Mouse Anti-CANX Recombinant Antibody (4F10) (CBMAB-C2006-LY)

SDS

Target: CANX

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 4F10

Application*: IC, IP, WB

Mouse Anti-CANX Recombinant Antibody (3H4A7) (CBMAB-C1225-LY)

SDS

Target: CANX

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Dog, Chicken, Fish, Human, Monkey, Mouse, Pig, Rabbit, Rat, Frog, Bear

Clone: 3H4A7

Application*: E, IC/IF, P, WB

Mouse Anti-CANX Recombinant Antibody (37/Calnexin) (CBMAB-C1032-LY)

SDS

Target: CANX

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Dog, Mouse, Rat

Clone: 37/Calnexin

Application*: WB, IH, IP

Mouse Anti-CANX Recombinant Antibody (1D4) (CBMAB-C0500-LY)

SDS

Target: CANX

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: 1D4

Application*: E, C, WB

Mouse Anti-CANX Recombinant Antibody (1C2.2D11) (CBMAB-C0490-LY)

SDS

Target: CANX

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: 1C2.2D11

Application*: WB, IH, IC/IF, P, F

Mouse Anti-CANX Recombinant Antibody (6F12BE10) (CBMAB-1301-CN)

SDS

Target: CANX

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: 6F12BE10

Application*: F, IC, P, E, IP

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)

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