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CD276

CD276 (CD276 Molecule) is a Protein Coding gene. Diseases associated with CD276 include Neuroblastoma and Acute Cervicitis. Among its related pathways are T Cell Co-Signaling Pathway: Ligand-Receptor Interactions and NF-kappaB Signaling. Gene Ontology (GO) annotations related to this gene include receptor binding. An important paralog of this gene is LOC102723996.
Full Name
CD276 Molecule
Function
May participate in the regulation of T-cell-mediated immune response. May play a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. May be involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. Could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy. Both isoform 1 and isoform 2 appear to be redundant in their ability to modulate CD4 T-cell responses. Isoform 2 is shown to enhance the induction of cytotoxic T-cells and selectively stimulates interferon gamma production in the presence of T-cell receptor signaling.
Biological Process
Positive regulation of interferon-gamma production Source: HGNC-UCL
Positive regulation of T cell proliferation Source: HGNC-UCL
Regulation of cytokine production Source: GO_Central
Regulation of immune response Source: HGNC-UCL
T cell activation Source: UniProtKB
T cell receptor signaling pathway Source: GO_Central
Cellular Location
Membrane
Topology
Extracellular: 29-466
Helical: 467-487
Cytoplasmic: 488-534

Anti-CD276 antibodies

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Rabbit Anti-CD276 Recombinant Antibody (CBYY-0976) (CBMAB-0979-YY)

Datasheet SDS
Target: CD276
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBYY-0976
Application*: P, WB, F

Rabbit Anti-CD276 Recombinant Antibody (CBYY-0975) (CBMAB-0978-YY)

Datasheet SDS
Target: CD276
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBYY-0975
Application*: C

Mouse Anti-CD276 Recombinant Antibody (CBXC-2673) (CBMAB-C5438-CQ)

Datasheet SDS
Target: CD276
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Pig
Clone: CBXC-2673
Application*: E, IH, WB

Mouse Anti-CD276 Recombinant Antibody (CBXC-0201) (CBMAB-C5436-CQ)

Datasheet SDS
Target: CD276
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-0201
Application*: F, IH

Mouse Anti-CD276 Recombinant Antibody (20J12) (CBMAB-C4359-LY)

Datasheet SDS
Target: CD276
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 20J12
Application*: WB

Mouse Anti-CD276 Recombinant Antibody (FM276) (CBMAB-C5435-CQ)

Datasheet SDS
Target: CD276
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: FM276
Application*: F

Mouse Anti-CD276 Recombinant Antibody (3E5) (CBMAB-C5963-LY)

Datasheet SDS
Target: CD276
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 3E5
Application*: E, WB

Rat Anti-CD276 Recombinant Antibody (MJ18) (CBMAB-C3060-CQ)

Datasheet SDS
Target: CD276
Host: Rat
Antibody Isotype: IgG
Specificity: Mouse
Clone: MJ18
Application*: F

Mouse Anti-CD276 Recombinant Antibody (CBFYC-1203) (CBMAB-C1261-FY)

Datasheet SDS
Target: CD276
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-1203
Application*: F

Mouse Anti-CD276 (AA 237-358) Recombinant Antibody (CBFYC-1202) (CBMAB-C1260-FY)

Datasheet SDS
Target: CD276
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYC-1202
Application*: E, WB

Mouse Anti-CD276 Recombinant Antibody (CBFYC-1201) (CBMAB-C1259-FY)

Datasheet SDS
Target: CD276
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-1201
Application*: WB

Mouse Anti-CD276 Recombinant Antibody (CBFYC-1200) (CBMAB-C1258-FY)

Datasheet SDS
Target: CD276
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-1200
Application*: E, F, WB

Mouse Anti-CD276 Recombinant Antibody (7-517) (CBMAB-C1753-YY)

Datasheet SDS
Target: CD276
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 7-517
Application*: F, C, IF

Mouse Anti-CD276 Recombinant Antibody (CBFYC-1199) (CBMAB-C1257-FY)

Datasheet SDS
Target: CD276
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-1199
Application*: F

Mouse Anti-CD276 Recombinant Antibody (CBFYC-1198) (CBMAB-C1256-FY)

Datasheet SDS
Target: CD276
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-1198
Application*: F, IH

Rabbit Anti-CD276 Recombinant Antibody (SP206) (CBMAB-C10156-LY)

Datasheet SDS
Target: CD276
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: SP206
Application*: WB, F

Mouse Anti-CD276 Recombinant Antibody (CBFYC-1197) (CBMAB-C1255-FY)

Datasheet SDS
Target: CD276
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Chicken
Clone: CBFYC-1197
Application*: F

Mouse Anti-CD276 Recombinant Antibody (CBYY-1722) (CBMAB-2071-YY)

Datasheet SDS
Target: CD276
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-1722
Application*: WB, F, MC

Mouse Anti-CD276 Recombinant Antibody (CBYY-1660) (CBMAB-2009-YY)

Datasheet SDS
Target: CD276
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYY-1660
Application*: E, ED, WB, F, IC, IF

Mouse Anti-CD276 (Center) Recombinant Antibody (CBYY-0973) (CBMAB-0976-YY)

Datasheet SDS
Target: CD276
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-0973
Application*: F, P, WB

Mouse Anti-CD276 Recombinant Antibody (CBYY-0972) (CBMAB-0975-YY)

Datasheet SDS
Target: CD276
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-0972
Application*: WB

Mouse Anti-CD276 (AA 89-93) Recombinant Antibody (CBYY-0971) (CBMAB-0974-YY)

Datasheet SDS
Target: CD276
Host: Mouse
Specificity: Human
Clone: CBYY-0971
Application*: EC

Rat Anti-CD276 Recombinant Antibody (A042) (CBMAB-AP11438LY)

Datasheet SDS
Target: CD276
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: A042
Application*: FC

Mouse Anti-CD276 Recombinant Antibody (10B1212) (CBMAB-C2107-LY)

Datasheet SDS
Target: CD276
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 10B1212
Application*: F, IH

Mouse Anti-CD276 Recombinant Antibody (10B1213) (CBMAB-C2108-LY)

Datasheet SDS
Target: CD276
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 10B1213
Application*: F

Mouse Anti-CD276 Recombinant Antibody (10B1214) (CBMAB-C2109-LY)

Datasheet SDS
Target: CD276
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Chicken
Clone: 10B1214
Application*: F

Mouse Anti-CD276 Recombinant Antibody (13B122) (CBMAB-C2778-LY)

Datasheet SDS
Target: CD276
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 13B122
Application*: E, C, WB

Mouse Anti-CD276 Recombinant Antibody (1A6) (CBMAB-C3562-LY)

Datasheet SDS
Target: CD276
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: 1A6
Application*: E, WB

Mouse Anti-CD276 Recombinant Antibody (1B8) (CBMAB-C3676-LY)

Datasheet SDS
Target: CD276
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 1B8
Application*: E

Mouse Anti-CD276 Recombinant Antibody (2D9) (CBMAB-C4940-LY)

Datasheet SDS
Target: CD276
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 2D9
Application*: E

Mouse Anti-CD276 Recombinant Antibody (5F11) (CBMAB-C7538-LY)

Datasheet SDS
Target: CD276
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 5F11
Application*: E

Mouse Anti-CD276 Recombinant Antibody (6A1) (CBMAB-C7978-LY)

Datasheet SDS
Target: CD276
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 6A1
Application*: WB, E, P, F, IC/IF

Mouse Anti-CD276 Recombinant Antibody (6D1) (CBMAB-C8143-LY)

Datasheet SDS
Target: CD276
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 6D1
Application*: E, WB

Mouse Anti-CD276 Recombinant Antibody (7C10) (CBMAB-C8584-LY)

Datasheet SDS
Target: CD276
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 7C10
Application*: E, IF, WB

Mouse Anti-CD276 Recombinant Antibody (8F5) (CBMAB-C9186-LY)

Datasheet SDS
Target: CD276
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 8F5
Application*: E, WB

Mouse Anti-CD276 Recombinant Antibody (MIH42) (CBMAB-C1654-CN)

Datasheet SDS
Target: CD276
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: MIH42
Application*: IH, FC

Rat Anti-CD276 Recombinant Antibody (MIH35) (CBMAB-C10152-LY)

Datasheet SDS
Target: CD276
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Mouse, Human
Clone: MIH35
Application*: F

Mouse Anti-CD276 Recombinant Antibody (MM0104-20J12) (CBMAB-C10157-LY)

Datasheet SDS
Target: CD276
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: MM0104-20J12
Application*: WB, P, F

Rabbit Anti-CD276 Recombinant Antibody (SP265) (CBMAB-C10159-LY)

Datasheet SDS
Target: CD276
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: SP265
Application*: P

Rabbit Anti-CD276 Recombinant Antibody (CBR026F) (CBMAB-BT016LY)

Datasheet SDS
Target: CD276
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBR026F
Application*: WB, IP, IHC, ICC, F

Rabbit Anti-CD276 Recombinant Antibody (CBR025F) (CBMAB-BT017LY)

Datasheet SDS
Target: CD276
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBR025F
Application*: WB, IP, IHC, ICC, IHC-IF, F

Rabbit Anti-CD276 Recombinant Antibody (RM335) (CBMAB-BR082LY)

Datasheet SDS
Target: CD276
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: RM335
Application*: IHC, WB

Mouse Anti-CD276 Recombinant Antibody (1E7D1) (CBMAB-AP1018LY)

Datasheet SDS
Target: CD276
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 1E7D1
Application*: ELISA, WB

Rabbit Anti-CD276 Recombinant Antibody (CAP388) (CBMAB-AP1019LY)

Datasheet SDS
Target: CD276
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CAP388
Application*: IHC, WB

CD276 Matched Antibody Pair (215) (APMAB-215LY)

Datasheet SDS
Target: CD276
Specificity: Human
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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