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CD276

CD276 (CD276 Molecule) is a Protein Coding gene. Diseases associated with CD276 include Neuroblastoma and Acute Cervicitis. Among its related pathways are T Cell Co-Signaling Pathway: Ligand-Receptor Interactions and NF-kappaB Signaling. Gene Ontology (GO) annotations related to this gene include receptor binding. An important paralog of this gene is LOC102723996.
Full Name
CD276 Molecule
Alternative Names
CD276 Molecule; CD276 Antigen; Costimulatory Molecule; B7 Homolog 3; 4Ig-B7-H3; B7-H3; B7H3; B7RP-2;
Function
May participate in the regulation of T-cell-mediated immune response. May play a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. May be involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. Could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy. Both isoform 1 and isoform 2 appear to be redundant in their ability to modulate CD4 T-cell responses. Isoform 2 is shown to enhance the induction of cytotoxic T-cells and selectively stimulates interferon gamma production in the presence of T-cell receptor signaling.
Biological Process
Positive regulation of interferon-gamma production Source: HGNC-UCL
Positive regulation of T cell proliferation Source: HGNC-UCL
Regulation of cytokine production Source: GO_Central
Regulation of immune response Source: HGNC-UCL
T cell activation Source: UniProtKB
T cell receptor signaling pathway Source: GO_Central
Cellular Location
Membrane
Topology
Extracellular: 29-466
Helical: 467-487
Cytoplasmic: 488-534
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Anti-CD276 antibodies

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Rat Anti-CD276 Recombinant Antibody (AG18) (V2LY-0524-LY96)

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Target: CD276
Host: Rat
Antibody Isotype: IgG1, κ
Specificity: Mouse
Clone: AG18
Application*: B, F, In Vivo
In Vivo Assay Functional Assay
Datasheet SDS

Mouse Anti-CD276 Recombinant Antibody (CBT293) (V2LY-0625-LY3626)

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Target: CD276
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBT293
Application*: WB, P, IF, F, E
Datasheet SDS

Mouse Anti-CD276 Recombinant Antibody (CBT4390) (V2LY-0625-LY2528)

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Target: CD276
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT4390
Application*: IH, F
Datasheet SDS

CD276 Matched Antibody Pair (215) (APMAB-215LY)

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Target: CD276
Specificity: Human
Datasheet SDS

Rat Anti-CD276 Recombinant Antibody (MJ18) (CBMAB-C3060-CQ)

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Target: CD276
Host: Rat
Antibody Isotype: IgG1, κ
Specificity: Mouse
Clone: MJ18
Application*: F, in vivo
In Vivo Assay
Datasheet SDS

Mouse Anti-CD276 Recombinant Antibody (CBFYC-1198) (CBMAB-C1256-FY)

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Target: CD276
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYC-1198
Application*: E, WB
Datasheet SDS

Mouse Anti-CD276 Recombinant Antibody (CBFYC-1197) (CBMAB-C1255-FY)

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Target: CD276
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYC-1197
Application*: E, IF
Datasheet SDS

Mouse Anti-CD276 Recombinant Antibody (7C10) (CBMAB-C8584-LY)

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Target: CD276
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 7C10
Application*: E, IF, WB
Datasheet SDS

Mouse Anti-CD276 Recombinant Antibody (C2107) (CBMAB-C2107-LY)

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Target: CD276
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: C2107
Application*: F, IF, E
Datasheet SDS

Mouse Anti-CD276 Recombinant Antibody (CBYY-1722) (CBMAB-2071-YY)

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Target: CD276
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Mouse, Rat, Dog, Cattle
Clone: CBYY-1722
Application*: WB, IP, E, IF
Datasheet SDS

Mouse Anti-CD276 Recombinant Antibody (CBYY-1660) (CBMAB-2009-YY)

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Target: CD276
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: CBYY-1660
Application*: WB, IP, E, IF
Datasheet SDS

Rabbit Anti-CD276 Recombinant Antibody (CBYY-0975) (CBMAB-0978-YY)

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Target: CD276
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBYY-0975
Application*: E
Datasheet SDS

Mouse Anti-CD276 Recombinant Antibody (CBYY-0973) (CBMAB-0976-YY)

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Target: CD276
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse, Rat
Clone: CBYY-0973
Application*: WB, IP, E, IF, P
Datasheet SDS

Mouse Anti-CD276 Recombinant Antibody (CBYY-0972) (CBMAB-0975-YY)

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Target: CD276
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Mouse, Rat, Dog, Cattle
Clone: CBYY-0972
Application*: WB, IP, E, IF
Datasheet SDS

Mouse Anti-CD276 Recombinant Antibody (CBYY-0971) (CBMAB-0974-YY)

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Target: CD276
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat, Dog, Cattle
Clone: CBYY-0971
Application*: WB, IP, E, IF
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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