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CD86

CD86 (CD86 Molecule) is a Protein Coding gene. Diseases associated with CD86 include Gallbladder Squamous Cell Carcinoma and Myocarditis. Among its related pathways are Cytokine Signaling in Immune system and Th2 Differentiation Pathway. Gene Ontology (GO) annotations related to this gene include receptor binding and coreceptor activity. An important paralog of this gene is CD80.
Full Name
CD86 Molecule
Function
Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation (PubMed:7527824).
Also involved in the regulation of B cells function, plays a role in regulating the level of IgG1 produced. Upon CD40 engagement, activates NF-kappa-B signaling pathway via phospholipase C and protein kinase C activation (By similarity).
Isoform 2: Interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation.
(Microbial infection) Acts as a receptor for adenovirus subgroup B.
Biological Process
Activation of phospholipase C activity Source: UniProtKB
Activation of protein kinase C activity Source: UniProtKB
Adaptive immune response Source: UniProtKB-KW
B cell activation Source: UniProtKB
CD40 signaling pathway Source: UniProtKB
Cell surface receptor signaling pathway Source: GO_Central
Cellular response to lipopolysaccharide Source: GO_Central
Cytokine-mediated signaling pathway Source: Reactome
Immune response Source: GO_Central
Negative regulation of T cell proliferation Source: GO_Central
Positive regulation of cell population proliferation Source: ProtInc
Positive regulation of immunoglobulin production Source: UniProtKB
Positive regulation of interleukin-2 production Source: UniProtKB
Positive regulation of interleukin-4 production Source: UniProtKB
Positive regulation of lymphotoxin A production Source: UniProtKB
Positive regulation of NIK/NF-kappaB signaling Source: UniProtKB
Positive regulation of protein kinase B signaling Source: Reactome
Positive regulation of T cell proliferation Source: GO_Central
Positive regulation of T-helper 2 cell differentiation Source: UniProtKB
Positive regulation of transcription, DNA-templated Source: UniProtKB
T cell costimulation Source: GO_Central
Cellular Location
Cell membrane
Topology
Extracellular: 24-247
Helical: 248-268
Cytoplasmic: 269-329
PTM
Polyubiquitinated; which is promoted by MARCH8 and results in endocytosis and lysosomal degradation.

Anti-CD86 antibodies

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Target: CD86
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: A084
Application*: FC, IF, IHC, IP
Target: CD86
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: A083
Application*: Block, FC, IP, WB
Target: CD86
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CAP430
Application*: WB
Target: CD86
Host: Rabbit
Antibody Isotype: IgG
Specificity: Monkey, Human, Rat
Clone: CAP429
Application*: FC, ICC, IF, IHC, WB
Target: CD86
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: C86/1146
Application*: FC, IF, IHC, WB
Target: CD86
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CAP428
Application*: ELISA, WB
Target: CD86
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Rat
Clone: CAP427
Application*: FC, ICC, IF, IHC, IP, WB
Target: CD86
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CB149
Application*: IF, FC
Target: CD86
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CB148
Application*: IF, FC
Target: CD86
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CB147
Application*: IF, FC
Target: CD86
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBR029F
Application*: WB, IP, ICC
Target: CD86
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBR030F
Application*: WB, IP, IHC, ICC
Target: CD86
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Rat
Clone: CBAb058
Application*: WB, IH, IF, IP
Target: CD86
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: SPM600
Application*: F, IF, WB, P
Target: CD86
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-1866
Application*: F
Target: CD86
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXC-1863
Application*: E
Target: CD86
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-0277
Application*: F, IH, IP
Target: CD86
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: CBXC-1480
Application*: F, IH, IP
Target: CD86
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: PO3
Application*: F
Target: CD86
Host: Rat
Antibody Isotype: IgG
Specificity: Mouse
Clone: GL1
Application*: F, IF, IH, IP
Target: CD86
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Mouse
Clone: CBXC-1637
Application*: F, IH, IP
Target: CD86
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: BU63
Application*: F
Target: CD86
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C1614
Application*: F, N, WB
Target: CD86
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C1613
Application*: E
Target: CD86
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Rat
Clone: CBYY-C1612
Application*: E
Target: CD86
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C0625
Application*: E, F, WB
Target: CD86
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C0488
Application*: F
Target: CD86
Host: Rat
Antibody Isotype: IgG2b, κ
Specificity: Mouse
Clone: CBYY-C0466
Application*: F, IP
Target: CD86
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Mouse
Clone: CBYY-C0455
Application*: F, IH, IP
Target: CD86
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse, Rat
Clone: CBYY-C0145
Application*: F
Target: CD86
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYC-1476
Application*: EC
Target: CD86
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYC-1475
Application*: E
Target: CD86
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: CBFYC-1472
Application*: F, FN, C, IP
Target: CD86
Host: Rabbit
Antibody Isotype: IgG
Specificity: Monkey
Clone: CBFYC-1471
Application*: E
Target: CD86
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBFYC-1470
Application*: E
Target: CD86
Host: Mouse
Antibody Isotype: IgG1
Specificity: Chicken
Clone: CBFYC-1469
Application*: F
Target: CD86
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-1468
Application*: F, N, WB
Target: CD86
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-1466
Application*: F, IH, IP, WB
Target: CD86
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Mouse
Clone: CBFYC-1464
Application*: F, C, IP, WB
Target: CD86
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: CBFYC-0539
Application*: F, IH
Target: CD86
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: CBFYC-0477
Application*: F
Target: CD86
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYC-0454
Application*: F
Target: CD86
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: CBYY-1724
Application*: N
Target: CD86
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Rat
Clone: CBYY-1723
Application*: WB
Target: CD86
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-1698
Application*: WB, F, N, MC
Target: CD86
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYY-0988
Application*: E
Target: CD86
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-0986
Application*: WB, E
Target: CD86
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBYY-0985
Application*: E, WB
Target: CD86
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBYY-0984
Application*: E, WB
Target: CD86
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 4H4
Application*: WB, E
Target: CD86
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 2E6
Application*: WB, E
Target: CD86
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 3E5
Application*: IP, E
Target: CD86
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: MAB0803
Application*: P, F
Target: CD86
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: MAB0827
Application*: B, F
Target: CD86
Host: Rat
Antibody Isotype: IgG2b, κ
Specificity: Mouse
Clone: PO3.1
Application*: F
Target: CD86
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: mB7-2
Application*: B, F
Target: CD86
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: RMMP-2
Application*: F
Target: CD86
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: OX-48
Application*: F
Target: CD86
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBNH-030
Application*: E, WB
Target: CD86
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 10B2097
Application*: FC
Target: CD86
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3H1726
Application*: FC, IH, IP
Target: CD86
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: 7H3
Application*: WB
Target: CD86
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 7H172
Application*: E, C, WB
Target: CD86
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 7F35
Application*: F, N, WB
Target: CD86
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 6H8A4E2
Application*: E
Target: CD86
Host: Rat
Antibody Isotype: IgG2b, κ
Specificity: Mouse
Clone: 5K50
Application*: F, IP
Target: CD86
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Mouse
Clone: 5K260
Application*: F, IH, IP
Target: CD86
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 3F2
Application*: E, WB
Target: CD86
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 3D7
Application*: E, IP
Target: CD86
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 3A6
Application*: E, WB
Target: CD86
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 2C9
Application*: E
Target: CD86
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Mouse
Clone: 1PL19
Application*: F, C, IP, WB
Target: CD86
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 1F6
Application*: E
Target: CD86
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1B3
Application*: E, WB
Target: CD86
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 14L240
Application*: F, N, WB
Target: CD86
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 14D46
Application*: F, IH, IP
Target: CD86
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 13B144
Application*: E, WB
Target: CD86
Host: Mouse
Antibody Isotype: IgG
Specificity: Rat
Clone: 12
Application*: EC
Target: CD86
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 118
Application*: E, ED
Target: CD86
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 103
Application*: EC
Target: CD86
Host: Mouse
Antibody Isotype: IgG
Specificity: Rat
Clone: 1E1
Application*: ED
Target: CD86
Host: Rabbit
Antibody Isotype: IgG
Specificity: Monkey
Clone: 021
Application*: E
Target: CD86
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: 003
Application*: E
Target: CD86
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: 3H1731
Application*: F
Target: CD86
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: 2D10
Application*: F, C, IP
Target: CD86
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: 24F
Application*: F, C, P, FN
Target: CD86
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Monkey
Clone: 2331 FUN-1
Application*: F
Target: CD86
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Rat
Clone: 6B4A7
Application*: E, WB
Target: CD86 (B7-2)
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: 1GL-1
Application*: B, F
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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