CPNE6

This gene encodes a brain-specific member of the copine family, which is composed of calcium-dependent membrane-binding proteins. The gene product contains two N-terminal C2 domains, and one von Willebrand factor A domain. It may have a role in synaptic plasticity. [provided by RefSeq]

Full Name

copine VI (neuronal)

Function

Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes. Binds phospholipid membranes in a calcium-dependent manner (By similarity).

Plays a role in dendrite formation by melanocytes (PubMed:23999003).

Biological Process

Cell differentiation Source: UniProtKB-KW
Cellular response to calcium ion Source: GO_Central
Chemical synaptic transmission Source: ProtInc
Glycerophospholipid biosynthetic process Source: Reactome
Lipid metabolic process Source: ProtInc
Nervous system development Source: ProtInc
Positive regulation of dendrite extension Source: UniProtKB
Vesicle-mediated transport Source: ProtInc

Cellular Location

Endosome; Cell membrane; Cytoplasm; Clathrin-coated vesicle; Perikaryon; Dendrite. Mainly cytoplasmic in absence of calcium. Associated predominantly with membranes in presence of calcium. Translocates to the cell membrane in a calcium-dependent manner. Colocalized with transferrin in intracellular clathrin-coated membrane vesicles in a calcium-dependent manner.