CPNE6

This gene encodes a brain-specific member of the copine family, which is composed of calcium-dependent membrane-binding proteins. The gene product contains two N-terminal C2 domains, and one von Willebrand factor A domain. It may have a role in synaptic plasticity. [provided by RefSeq]

Full Name

copine VI (neuronal)

Function

Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes. Binds phospholipid membranes in a calcium-dependent manner (By similarity).

Plays a role in dendrite formation by melanocytes (PubMed:23999003).

Biological Process

Cell differentiation Source: UniProtKB-KW
Cellular response to calcium ion Source: GO_Central
Chemical synaptic transmission Source: ProtInc
Glycerophospholipid biosynthetic process Source: Reactome
Lipid metabolic process Source: ProtInc
Nervous system development Source: ProtInc
Positive regulation of dendrite extension Source: UniProtKB
Vesicle-mediated transport Source: ProtInc

Cellular Location

Endosome; Cell membrane; Cytoplasm; Clathrin-coated vesicle; Perikaryon; Dendrite. Mainly cytoplasmic in absence of calcium. Associated predominantly with membranes in presence of calcium. Translocates to the cell membrane in a calcium-dependent manner. Colocalized with transferrin in intracellular clathrin-coated membrane vesicles in a calcium-dependent manner.

Anti-CPNE6 antibodies

Mouse Anti-CPNE6 Recombinant Antibody (CBXC-0538) (CBMAB-C3135-CQ)

Datasheet

SDS

Target: CPNE6

Host: Mouse

Antibody Isotype: IgG3, κ

Specificity: Human

Clone: CBXC-0538

Application*: E, WB

Mouse Anti-CPNE6 Recombinant Antibody (CBWJC-3026) (CBMAB-C4182WJ)

Datasheet

SDS

Target: CPNE6

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBWJC-3026

Application*: E, WB

Mouse Anti-CPNE6 Recombinant Antibody (6.4_1B4) (CBMAB-1422-CN)

Datasheet

SDS

Target: CPNE6

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: 6.4_1B4

Application*: WB, IP, IF

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)