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CTH

CTH (Cystathionine Gamma-Lyase) is a Protein Coding gene. Diseases associated with CTH include Cystathioninuria and Methionine Adenosyltransferase I/Iii Deficiency. Among its related pathways are One carbon pool by folate and Viral mRNA Translation. Gene Ontology (GO) annotations related to this gene include calmodulin binding and carbon-sulfur lyase activity.

Full Name

Cystathionine Gamma-Lyase

Function

Catalyzes the last step in the trans-sulfuration pathway from methionine to cysteine. Has broad substrate specificity. Converts cystathionine to cysteine, ammonia and 2-oxobutanoate. Converts two cysteine molecules to lanthionine and hydrogen sulfide. Can also accept homocysteine as substrate. Specificity depends on the levels of the endogenous substrates. Generates the endogenous signaling molecule hydrogen sulfide (H2S), and so contributes to the regulation of blood pressure. Acts as a cysteine-protein sulfhydrase by mediating sulfhydration of target proteins: sulfhydration consists of converting -SH groups into -SSH on specific cysteine residues of target proteins such as GAPDH, PTPN1 and NF-kappa-B subunit RELA, thereby regulating their function.

Biological Process

Cellular response to leukemia inhibitory factor Source: Ensembl
Cysteine biosynthetic process Source: UniProtKB
Cysteine biosynthetic process via cystathionine Source: BHF-UCL
Cysteine metabolic process Source: ProtInc
Endoplasmic reticulum unfolded protein response Source: UniProtKB
Hydrogen sulfide biosynthetic process Source: UniProtKB
Negative regulation of apoptotic signaling pathway Source: Ensembl
Positive regulation of aortic smooth muscle cell differentiation Source: BHF-UCL
Positive regulation of I-kappaB kinase/NF-kappaB signaling Source: Ensembl
Positive regulation of NF-kappaB transcription factor activity Source: Ensembl
Protein homotetramerization Source: UniProtKB
Protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine Source: UniProtKB
Protein sulfhydration Source: UniProtKB
Sulfur amino acid catabolic process Source: Reactome
Transsulfuration Source: BHF-UCL

Cellular Location

Cytoplasm

Involvement in disease

Cystathioninuria (CSTNU):
Autosomal recessive phenotype characterized by abnormal accumulation of plasma cystathionine, leading to increased urinary excretion.

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Anti-CTH antibodies

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CTH Matched Antibody Pair (309) (APMAB-309LY)

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Target: CTH

Specificity: Human

Mouse Anti-CTH Recombinant Antibody (CBXC-2728) (CBMAB-C4882-CQ)

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Target: CTH

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBXC-2728

Application*: E, WB

Mouse Anti-CTH Recombinant Antibody (CBFYC-2385) (CBMAB-C2458-FY)

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Target: CTH

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human, Mouse, Rat

Clone: CBFYC-2385

Application*: WB, IP, IF, E, P

Mouse Anti-CTH Recombinant Antibody (CBLG1-379) (CBMAB-G1487-LY)

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Target: CTH

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse, Rat

Clone: CBLG1-379

Application*: WB, IP, IF, E, P

Rabbit Anti-CTH Recombinant Antibody (CBWJC-3330) (V2LY-0125-LY262)

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Target: CTH

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: CBWJC-3330

Application*: WB, IP

Mouse Anti-CTH Recombinant Antibody (CBWJC-3329) (V2LY-0125-LY261)

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Target: CTH

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse, Rat, Dog

Clone: CBWJC-3329

Application*: WB, IH, IF

Mouse Anti-CTH Recombinant Antibody (CBWJC-3328) (V2LY-0125-LY260)

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Target: CTH

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Mouse

Clone: CBWJC-3328

Application*: WB

Mouse Anti-CTH Recombinant Antibody (CBXC-1973) (V2LY-0125-LY258)

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Target: CTH

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human, Mouse, Rat, Cattle, Pig

Clone: CBXC-1973

Application*: WB, IP, IF, E, P

Mouse Anti-CTH Recombinant Antibody (4E1-1B7) (V2LY-0125-LY256)

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Target: CTH

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Guinea pig, Human

Clone: 4E1-1B7

Application*: E, WB

CTH Matched Antibody Pair (313) (APMAB-313LY)

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Target: CTH

Specificity: Human

CTH Matched Antibody Pair (312) (APMAB-312LY)

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Target: CTH

Specificity: Human

CTH Matched Antibody Pair (311) (APMAB-311LY)

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Target: CTH

Specificity: Human

CTH Matched Antibody Pair (310) (APMAB-310LY)

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Target: CTH

Specificity: Human

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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