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CTH

CTH (Cystathionine Gamma-Lyase) is a Protein Coding gene. Diseases associated with CTH include Cystathioninuria and Methionine Adenosyltransferase I/Iii Deficiency. Among its related pathways are One carbon pool by folate and Viral mRNA Translation. Gene Ontology (GO) annotations related to this gene include calmodulin binding and carbon-sulfur lyase activity.

Full Name

Cystathionine Gamma-Lyase

Function

Catalyzes the last step in the trans-sulfuration pathway from methionine to cysteine. Has broad substrate specificity. Converts cystathionine to cysteine, ammonia and 2-oxobutanoate. Converts two cysteine molecules to lanthionine and hydrogen sulfide. Can also accept homocysteine as substrate. Specificity depends on the levels of the endogenous substrates. Generates the endogenous signaling molecule hydrogen sulfide (H2S), and so contributes to the regulation of blood pressure. Acts as a cysteine-protein sulfhydrase by mediating sulfhydration of target proteins: sulfhydration consists of converting -SH groups into -SSH on specific cysteine residues of target proteins such as GAPDH, PTPN1 and NF-kappa-B subunit RELA, thereby regulating their function.

Biological Process

Cellular response to leukemia inhibitory factor Source: Ensembl
Cysteine biosynthetic process Source: UniProtKB
Cysteine biosynthetic process via cystathionine Source: BHF-UCL
Cysteine metabolic process Source: ProtInc
Endoplasmic reticulum unfolded protein response Source: UniProtKB
Hydrogen sulfide biosynthetic process Source: UniProtKB
Negative regulation of apoptotic signaling pathway Source: Ensembl
Positive regulation of aortic smooth muscle cell differentiation Source: BHF-UCL
Positive regulation of I-kappaB kinase/NF-kappaB signaling Source: Ensembl
Positive regulation of NF-kappaB transcription factor activity Source: Ensembl
Protein homotetramerization Source: UniProtKB
Protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine Source: UniProtKB
Protein sulfhydration Source: UniProtKB
Sulfur amino acid catabolic process Source: Reactome
Transsulfuration Source: BHF-UCL

Cellular Location

Cytoplasm

Involvement in disease

Cystathioninuria (CSTNU):
Autosomal recessive phenotype characterized by abnormal accumulation of plasma cystathionine, leading to increased urinary excretion.

Anti-CTH antibodies

Rabbit Anti-CTH Recombinant Antibody (CBWJC-3330) (CBMAB-C4536WJ)

SDS

Target: CTH

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: CBWJC-3330

Application*: WB, IP

Mouse Anti-CTH Recombinant Antibody (CBWJC-3329) (CBMAB-C4535WJ)

SDS

Target: CTH

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Dog, Monkey

Clone: CBWJC-3329

Application*: WB, IH

Mouse Anti-CTH Recombinant Antibody (CBWJC-3328) (CBMAB-C4534WJ)

SDS

Target: CTH

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human, Dog, Monkey

Clone: CBWJC-3328

Application*: WB, IH

Mouse Anti-CTH Recombinant Antibody (CBXC-2728) (CBMAB-C4882-CQ)

SDS

Target: CTH

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse, Rat

Clone: CBXC-2728

Application*: E, IF, IH, WB, IR

Mouse Anti-CTH Recombinant Antibody (CBXC-1973) (CBMAB-C4881-CQ)

SDS

Target: CTH

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human, Dog

Clone: CBXC-1973

Application*: WB, IH, P

Mouse Anti-CTH Recombinant Antibody (CBFYC-2385) (CBMAB-C2458-FY)

SDS

Target: CTH

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBFYC-2385

Application*: P, WB

Mouse Anti-CTH Recombinant Antibody (CBLG1-379) (CBMAB-G1487-LY)

SDS

Target: CTH

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse, Rat

Clone: CBLG1-379

Application*: E (IA), WB

Mouse Anti-CTH Recombinant Antibody (620) (CBMAB-AP1764LY)

SDS

Target: CTH

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse, Rat

Clone: 620

Application*: ELISA, IF, IHC, WB

Mouse Anti-CTH Recombinant Antibody (CF119) (CBMAB-FT298LY)

SDS

Target: CTH

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse, Rat

Clone: CF119

Application*: ELISA, WB, IHC, IF

Rabbit Anti-CTH Recombinant Antibody (D1N1D) (CBMAB-CP0397-LY)

SDS

Target: CTH

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: D1N1D

Application*: WB

Rabbit Anti-CTH Recombinant Antibody (D4E9J) (CBMAB-CP0396-LY)

SDS

Target: CTH

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Monkey

Clone: D4E9J

Application*: WB

Mouse Anti-CTH Recombinant Antibody (CBCNC-452) (CBMAB-C3062-CN)

SDS

Target: CTH

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBCNC-452

Application*: WB, P, FC, IF

Mouse Anti-CTH Recombinant Antibody (CBCNC-451) (CBMAB-C3061-CN)

SDS

Target: CTH

Host: Mouse

Specificity: Rat

Clone: CBCNC-451

Application*: WB, ICC, P, IH-F, E

Mouse Anti-CTH Recombinant Antibody (S51) (CBMAB-C3060-CN)

SDS

Target: CTH

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human, Mouse

Clone: S51

Application*: E, IH, WB

Mouse Anti-CTH Recombinant Antibody (OTI2D6) (CBMAB-C3059-CN)

SDS

Target: CTH

Host: Mouse

Antibody Isotype: IgG1

Specificity: Dog, Human, Monkey

Clone: OTI2D6

Application*: IH, WB

Mouse Anti-CTH Recombinant Antibody (4E1-1B7) (CBMAB-C6841-LY)

SDS

Target: CTH

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 4E1-1B7

Application*: E, WB

Mouse Anti-CTH Recombinant Antibody (2D6) (CBMAB-C4913-LY)

SDS

Target: CTH

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Monkey, Dog

Clone: 2D6

Application*: WB, P

Mouse Anti-CTH Recombinant Antibody (1E12) (CBMAB-C3917-LY)

SDS

Target: CTH

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 1E12

Application*: P, WB

CTH Matched Antibody Pair (313) (APMAB-313LY)

SDS

Target: CTH

Specificity: Human

CTH Matched Antibody Pair (312) (APMAB-312LY)

SDS

Target: CTH

Specificity: Human

CTH Matched Antibody Pair (311) (APMAB-311LY)

SDS

Target: CTH

Specificity: Human

CTH Matched Antibody Pair (310) (APMAB-310LY)

SDS

Target: CTH

Specificity: Human

CTH Matched Antibody Pair (309) (APMAB-309LY)

SDS

Target: CTH

Specificity: Human

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)

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