DDX54

This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The nucleolar protein encoded by this gene interacts in a hormone-dependent manner with nuclear receptors, and represses their transcriptional activity. Alternative splice variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

DEAD-Box Helicase 54

Has RNA-dependent ATPase activity. Represses the transcriptional activity of nuclear receptors.

Intracellular estrogen receptor signaling pathway Source: UniProtKB
RNA metabolic process Source: UniProtKB
RNA processing Source: UniProtKB
rRNA processing Source: GO_Central

Nucleolus