DFFA

Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Full Name
DNA Fragmentation Factor Subunit Alpha
Function
Inhibitor of the caspase-activated DNase (DFF40).
Biological Process
Apoptotic DNA fragmentation Source: Reactome
Chaperone-mediated protein folding Source: CAFA
Negative regulation of apoptotic DNA fragmentation Source: MGI
Negative regulation of deoxyribonuclease activity Source: CAFA
Negative regulation of execution phase of apoptosis Source: BHF-UCL
Positive regulation of apoptotic process Source: Ensembl
Regulation of apoptotic process Source: GO_Central
Thymocyte apoptotic process Source: Ensembl
Cellular Location
Cytoplasm
PTM
Caspase-3 cleaves DFF45 at 2 sites to generate an active factor.
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Anti-DFFA antibodies

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Mouse Anti-DFFA Recombinant Antibody (CBYY-I1006) (CBMAB-I2174-YY)

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Target: DFFA
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: CBYY-I1006
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-DFFA Recombinant Antibody (3A11) (CBMAB-D0752-YC)

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Target: DFFA
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 3A11
Application*: E, PLA, WB
Datasheet SDS

Mouse Anti-DFFA Recombinant Antibody (D0750) (CBMAB-D0750-YC)

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Target: DFFA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: D0750
Application*: WB
Datasheet SDS

Mouse Anti-DFFA Recombinant Antibody (D0749) (CBMAB-D0749-YC)

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Target: DFFA
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: D0749
Application*: WB, IP, IF, E, P
Datasheet SDS

Mouse Anti-DFFA Recombinant Antibody (D0748) (CBMAB-D0748-YC)

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Target: DFFA
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: D0748
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-DFFA Recombinant Antibody (D0743) (CBMAB-D0743-YC)

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Target: DFFA
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Mouse, Rat
Clone: D0743
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-DFFA Recombinant Antibody (CBT3777) (V2LY-0625-LY1321)

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Target: DFFA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT3777
Application*: F
Datasheet SDS

Rabbit Anti-DFFA Recombinant Antibody (EG949) (V2LY-0425-LY220)

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Target: DFFA
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: EG949
Application*: WB, P, F
Datasheet SDS

DFFA Matched Antibody Pair (336) (APMAB-336LY)

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Target: DFFA
Specificity: Human
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DFFA Matched Antibody Pair (335) (APMAB-335LY)

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Target: DFFA
Specificity: Human
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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