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Rabbit Anti-DFFA Recombinant Antibody (EG949) (V2LY-0425-LY220)


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Summary

Host Animal
Rabbit
Specificity
Human
Clone
EG949
Antibody Isotype
IgG
Application
WB, IHC-P, FC

Basic Information

Immunogen
Recombinant protein within human icad aa 37-137.
Host Species
Rabbit
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:1,000
IHC-P1:200-1:500
FC1:50-1:100

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
BSA & Glycerol & TBS
Preservative
Sodium Azide
Concentration
1 mg/ml
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
DNA Fragmentation Factor Subunit Alpha
Entrez Gene ID
1676
UniProt ID
O00273
Function
Inhibitor of the caspase-activated DNase (DFF40).
Biological Process
Apoptotic DNA fragmentation Source: Reactome
Chaperone-mediated protein folding Source: CAFA
Negative regulation of apoptotic DNA fragmentation Source: MGI
Negative regulation of deoxyribonuclease activity Source: CAFA
Negative regulation of execution phase of apoptosis Source: BHF-UCL
Positive regulation of apoptotic process Source: Ensembl
Regulation of apoptotic process Source: GO_Central
Thymocyte apoptotic process Source: Ensembl
Cellular Location
Cytoplasm
PTM
Caspase-3 cleaves DFF45 at 2 sites to generate an active factor.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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