DNAJA1

This gene encodes a member of the DnaJ family of proteins, which act as heat shock protein 70 cochaperones. Heat shock proteins facilitate protein folding, trafficking, prevention of aggregation, and proteolytic degradation. Members of this family are characterized by a highly conserved N-terminal J domain, a glycine/phenylalanine-rich region, four CxxCxGxG zinc finger repeats, and a C-terminal substrate-binding domain. The J domain mediates the interaction with heat shock protein 70 to recruit substrates and regulate ATP hydrolysis activity. In humans, this gene has been implicated in positive regulation of virus replication through co-option by the influenza A virus. Several pseudogenes of this gene are found on other chromosomes.

Full Name

DnaJ (Hsp40) homolog, subfamily A, member 1

Function

Co-chaperone for HSPA8/Hsc70 (PubMed:10816573).

Stimulates ATP hydrolysis, but not the folding of unfolded proteins mediated by HSPA1A (in vitro) (PubMed:24318877).

Plays a role in protein transport into mitochondria via its role as co-chaperone. Functions as co-chaperone for HSPA1B and negatively regulates the translocation of BAX from the cytosol to mitochondria in response to cellular stress, thereby protecting cells against apoptosis (PubMed:14752510).

Promotes apoptosis in response to cellular stress mediated by exposure to anisomycin or UV (PubMed:24512202).

Biological Process

Androgen receptor signaling pathway Source: Ensembl
DNA damage response, detection of DNA damage Source: Ensembl
Flagellated sperm motility Source: Ensembl
Negative regulation of apoptotic process Source: UniProtKB
Negative regulation of establishment of protein localization to mitochondrion Source: ParkinsonsUK-UCL
Negative regulation of JUN kinase activity Source: UniProtKB
Negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway Source: ParkinsonsUK-UCL
Negative regulation of protein ubiquitination Source: ParkinsonsUK-UCL
Positive regulation of apoptotic process Source: UniProtKB
Protein folding Source: ProtInc
Protein localization to mitochondrion Source: UniProtKB
Regulation of protein transport Source: UniProtKB
Response to heat Source: InterPro
Response to unfolded protein Source: ProtInc
Spermatogenesis Source: Ensembl
Toxin transport Source: Ensembl

Cellular Location

Nucleus; Mitochondrion; Microsome; Cytoplasm; Membrane; Perinuclear region. Primarily associated with microsomes. A minor proportion is associated with mitochondria (By similarity). Primarily cytoplasmic. A minor proportion is associated with nuclei.