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ITGA7

The protein encoded by this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. They mediate a wide spectrum of cell-cell and cell-matrix interactions, and thus play a role in cell migration, morphologic development, differentiation, and metastasis. This protein functions as a receptor for the basement membrane protein laminin-1. It is mainly expressed in skeletal and cardiac muscles and may be involved in differentiation and migration processes during myogenesis. Defects in this gene are associated with congenital myopathy. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq]
Full Name
integrin, alpha 7
Function
Integrin alpha-7/beta-1 is the primary laminin receptor on skeletal myoblasts and adult myofibers. During myogenic differentiation, it may induce changes in the shape and mobility of myoblasts, and facilitate their localization at laminin-rich sites of secondary fiber formation. It is involved in the maintenance of the myofibers cytoarchitecture as well as for their anchorage, viability and functional integrity. Isoform Alpha-7X2B and isoform Alpha-7X1B promote myoblast migration on laminin 1 and laminin 2/4, but isoform Alpha-7X1B is less active on laminin 1 (In vitro). Acts as Schwann cell receptor for laminin-2. Acts as a receptor of COMP and mediates its effect on vascular smooth muscle cells (VSMCs) maturation (By similarity).
Required to promote contractile phenotype acquisition in differentiated airway smooth muscle (ASM) cells.
Biological Process
Cell-matrix adhesionManual Assertion Based On ExperimentTAS:ProtInc
Endodermal cell differentiationManual Assertion Based On ExperimentIEP:UniProtKB
Heterotypic cell-cell adhesionManual Assertion Based On ExperimentIMP:UniProtKB
Integrin-mediated signaling pathwayIEA:UniProtKB-KW
Muscle organ developmentManual Assertion Based On ExperimentTAS:ProtInc
Regulation of cell shapeIEA:UniProtKB-KW
Skeletal muscle tissue developmentIEA:Ensembl
Cellular Location
Membrane
Involvement in disease
Muscular dystrophy congenital due to integrin alpha-7 deficiency (MDCI):
A form of congenital muscular dystrophy. Patients present at birth, or within the first few months of life, with hypotonia, muscle weakness and often with joint contractures.
Topology
Extracellular: 34-1082
Helical: 1083-1103
Cytoplasmic: 1104-1181
PTM
ADP-ribosylated on at least two sites of the extracellular domain in skeletal myotubes.
A 70 kDa form is created by proteolytic cleavage. Cleavage is elevated during myogenic differentiation and the cleaved form enhances cell adhesion and spreading on laminin.

Anti-ITGA7 antibodies

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Target: ITGA7
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: 334908
Application*: E, FC
Target: ITGA7
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse
Clone: 3C12
Application*: FC
Target: ITGA7
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat, Rabbit, Yeast
Clone: MCP72
Application*: IH, WB
Target: ITGA7
Host: Mouse
Antibody Isotype: IgG2c
Specificity: Human
Clone: 9.1
Application*: F, B, IF, IP, WB
Target: ITGA7
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 1F4
Application*: E, WB
Target: ITGA7
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse
Clone: 6A11
Application*: FC, N
Target: ITGA7
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 8G2
Application*: WB
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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