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KDM5B

This gene encodes a lysine-specific histone demethylase that belongs to the jumonji/ARID domain-containing family of histone demethylases. The encoded protein is capable of demethylating tri-, di- and monomethylated lysine 4 of histone H3. This protein plays a role in the transcriptional repression or certain tumor suppressor genes and is upregulated in certain cancer cells. This protein may also play a role in genome stability and DNA repair. Alternate splicing results in multiple transcript variants.
Full Name
lysine demethylase 5B
Function
Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code (PubMed:24952722, PubMed:27214403, PubMed:28262558).
Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5 (PubMed:24952722).
In contrast, may act as a tumor suppressor for melanoma. Represses the CLOCK-ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2 (By similarity).
Biological Process
Branching involved in mammary gland duct morphogenesisIEA:Ensembl
Cellular response to fibroblast growth factor stimulusIEA:Ensembl
Cellular response to leukemia inhibitory factorIEA:Ensembl
Chromatin remodelingManual Assertion Based On ExperimentIBA:GO_Central
Histone H3-K4 demethylationManual Assertion Based On ExperimentIDA:UniProtKB
Lens fiber cell differentiationIEA:Ensembl
Mammary duct terminal end bud growthIEA:Ensembl
Negative regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIDA:GDB
Positive regulation of gene expressionIEA:Ensembl
Positive regulation of mammary gland epithelial cell proliferationIEA:Ensembl
Post-embryonic developmentIEA:Ensembl
Regulation of estradiol secretionIEA:Ensembl
Response to fungicideIEA:Ensembl
Rhythmic processIEA:UniProtKB-KW
Single fertilizationIEA:Ensembl
Uterus morphogenesisIEA:Ensembl
Cellular Location
Nucleus
Involvement in disease
Mental retardation, autosomal recessive 65 (MRT65):
A form of mental retardation, a disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRT65 patients have moderate to severe intellectual disability, developmental delay, and facial dysmorphism. Camptodactyly is present in some patients.
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Anti-KDM5B antibodies

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Mouse Anti-KDM5B Recombinant Antibody (CBYJL-038) (CBMAB-L0068-YJ)

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Target: KDM5B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJL-038
Application*: WB
Datasheet SDS

Mouse Anti-KDM5B Recombinant Antibody (CBYJL-037) (CBMAB-L0067-YJ)

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Target: KDM5B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJL-037
Application*: WB, IH, P
Datasheet SDS

Mouse Anti-KDM5B Recombinant Antibody (CBYJL-036) (CBMAB-L0066-YJ)

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Target: KDM5B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJL-036
Application*: WB, F, E, IH
Datasheet SDS

Mouse Anti-KDM5B Recombinant Antibody (CBT4543) (V2LY-0625-LY270)

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Target: KDM5B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT4543
Application*: F
Datasheet SDS

Mouse Anti-KDM5B Recombinant Antibody (EG1781) (CBMAB-EN2124-LY)

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Target: KDM5B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: EG1781
Application*: WB
Datasheet SDS

Mouse Anti-KDM5B Recombinant Antibody (EG1709) (CBMAB-EN2047-LY)

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Target: KDM5B
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: EG1709
Application*: ELISA, WB
Datasheet SDS

Rabbit Anti-KDM5B Recombinant Antibody (E2X6N) (CBMAB-CP1260-LY)

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Target: KDM5B
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Monkey
Clone: E2X6N
Application*: WB, IP, CI, CI-seq
Datasheet SDS

Rabbit Anti-KDM5B Recombinant Antibody (CBLY1-070) (CBMAB-K0698-LY)

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Target: KDM5B
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse, Rat, Human
Clone: CBLY1-070
Application*: WB, IC/IF
Datasheet SDS

Mouse Anti-KDM5B Recombinant Antibody (M80501) (CBMAB-K0705-LY)

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Target: KDM5B
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Rat
Clone: M80501
Application*: WB
Datasheet SDS

Mouse Anti-KDM5B Recombinant Antibody (CL1147) (CBMAB-K0703-LY)

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Target: KDM5B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CL1147
Application*: WB
Datasheet SDS

Mouse Anti-KDM5B Recombinant Antibody (CL1129) (CBMAB-K0702-LY)

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Target: KDM5B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CL1129
Application*: IH, WB
Datasheet SDS

Mouse Anti-KDM5B Recombinant Antibody (7H3D7) (CBMAB-K0701-LY)

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Target: KDM5B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 7H3D7
Application*: E, WB, F
Datasheet SDS

Mouse Anti-KDM5B Recombinant Antibody (4F12) (CBMAB-K0700-LY)

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Target: KDM5B
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 4F12
Application*: E, WB
Datasheet SDS

Mouse Anti-KDM5B Recombinant Antibody (JARIA3D4) (CBMAB-0374-WJ)

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Target: KDM5B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: JARIA3D4
Application*: DB
Datasheet SDS

Mouse Anti-KDM5B Recombinant Antibody (8C199) (CBMAB-0275-WJ)

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Target: KDM5B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 8C199
Application*: DB, WB
Datasheet SDS

Mouse Anti-KDM5B Recombinant Antibody (1G10) (CBMAB-0100-WJ)

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Target: KDM5B
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 1G10
Application*: E, IF, IH, WB
Datasheet SDS

Rabbit Anti-KDM5B Recombinant Antibody (CBLXK-008) (CBMAB-2213CQ)

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Target: KDM5B
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Monkey
Clone: CBLXK-008
Application*: WB, IP
Datasheet SDS

Mouse Anti-KDM5B Recombinant Antibody (CBLXK-007) (CBMAB-2212CQ)

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Target: KDM5B
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBLXK-007
Application*: E, WB
Datasheet SDS
More Infomation
Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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